数字农科院2.0

Atypical Classical Swine Fever Infection Changes Interleukin Gene Expression in Pigs

文献类型： 外文期刊

作者： Sun, Y. K.;Sun, Y. K.;Zhang, X. M.;Du, M.;Li, Y. X.;Pan, H. B.;Yan, Y. L.;Yang, Y. A.

作者机构：

关键词： CSFV;RT-PCR;Interleukin;Viral Replication;Temperature;Leukocyte

期刊名称： ISRAEL JOURNAL OF VETERINARY MEDICINE

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收录情况： SCI

摘要： Several studies have highlighted the important role of cytokines in disease development of classical swine fever virus (CSFV) infection. In the present study, we examined the changes of body temperature, viral replication and leukocytes, and the kinetics of four porcine interleukins (ILs) in serum from pigs infected with CSFV strains which lead to the atypical CSF during 45 days post infection (dpi). The results showed that compared to those uninfected pigs with CSFV, CSFV-infected pigs had higher temperature and viral replication while showing less leukocytes. Furthermore, using reverse transcription polymerase chain reaction (RT-PCR), the cytokines IL-1, IL-2 and IL-4 in white blood cells of pigs were measured showing increased levels after CSFV infection. However, the cytokine IL-8 level of the CSFV-infected pigs was downregulated before 10 dpi and peaked at 25 dpi. These findings may indicate that IL-1, IL-2, IL-4 and IL-8 are involved in the immune response during CSFV infection.

分类号： S85

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