数字农科院2.0

Immune responses to modified live virus vaccines developed from classical or highly pathogenic PRRSV following challenge with a highly pathogenic PRRSV strain

文献类型: 外文期刊

作者: Wang, Gang;Yu, Ying;Zhang, Chong;Tu, Yabin;Tong, Jie;Liu, Yonggang;Chang, Yafei;Jiang, Chenggang;Wang, Shujie;Cai, Xuehui;Yu, Ying;Zhou, En-Min;Zhang, Chong

作者机构:

关键词: Highly pathogenic PRRSV;PRRSV vaccine;Immune responses

期刊名称: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Modified live virus vaccines (MLVs) are used on swine farms to control porcine reproductive and respiratory syndrome virus (PRRSV). MLVs from classical PRRSV (C-PRRSV) provide some protection against emergent highly pathogenic PRRSV (HP-PRRSV). This study characterized the protective efficacy and immune response to MLVs from C-PRRSV (CH-1R) or HP-PRRSV (HuN4-F112) in a challenge using HP-PRRSV (HuN4). The outcomes were clinical signs of disease, pathological changes in the thymus and lungs, viremia, and humoral and cellular immune responses. CH-1R provided some protection against challenge with HuN4, while HuN4-F112 was protective in the HuN4 challenge. Compared to unvaccinated piglets, the vaccinated piglets had milder symptoms and fewer pathological changes in the lung and thymus. Piglets vaccinated with HuN4-F112 had higher antibody titers and lower viral loads than piglets vaccinated with CH-1R post challenge. The differences in outcome between the MLVs suggested that underlying differences in the immune responses might warrant further study. (C) 2016 Elsevier Ltd. All rights reserved.

分类号: R392

  • 相关文献

[1]The Isolation and Characterization of a Novel Group III-Classified Getah Virus from a Commercial Modified Live Vaccine against PRRSV. Xintao Gao,Jialei Li,Tong Wu,Jinping Dou,Wenrong Zhang,Hong Jia,Zhifang Zhang,Xingjian Liu,Yinü Li. 2023

[2]Characterization of thymus atrophy in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus. He, Yuli,Wang, Gang,Liu, Yonggang,Shi, Wenda,Han, Zifeng,Wu, Jianan,Jiang, Chenggang,Wang, Shujie,Hu, Shouping,Wen, Huiqiang,Dong, Jianguo,Liu, He,Cai, Xuehui. 2012

[3]Immunization of pigs with a type 2 modified live PRRSV vaccine prevents the development of a deadly long lasting hyperpyrexia in a challenge study with highly pathogenic PRRSV JX143. Wei, Zuzhang,Zhang, Jianwu,Zhuang, Jinshan,Sun, Zhi,Gao, Fei,Yuan, Shishan. 2013

[4]Comparative analysis of apoptotic changes in peripheral immune organs and lungs following experimental infection of piglets with highly pathogenic and classical porcine reproductive and respiratory syndrome virus. Wang, Gang,He, Yuli,Tu, Yabin,Liu, Yonggang,Han, Zifeng,Jiang, Chenggang,Wang, Shujie,Shi, Wenda,Cai, Xuehui,Zhou, En-Min,Han, Zifeng. 2014

[5]Evaluation of the Pathogenicity of a Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Variant in Piglets. Wei Tian-chao,Tian Zhi-jun,An Tong-qing,Jiang Yi-feng,Xiao Yan,Hu Shou-ping,Peng Jin-mei,Hao Xiao-fang,Zhang Shan-rui,Tong Guang-zhi,Zhou Yan-jun,Tong Guang-zhi,Wei Tian-chao. 2011

[6]PA-X protein contributes to virulence of triple-reassortant H1N2 influenza virus by suppressing early immune responses in swine. Xu, Guanlong,Zhang, Xuxiao,Hu, Zhe,Sun, Honglei,Xiong, Xin,Jiang, Ming,He, Qiming,Wang, Yu,Pu, Juan,Guo, Xin,Yang, Hanchun,Liu, Jinhua,Sun, Yipeng,Xu, Guanlong,Zhang, Xuxiao,Hu, Zhe,Sun, Honglei,Xiong, Xin,Jiang, Ming,He, Qiming,Wang, Yu,Pu, Juan,Guo, Xin,Yang, Hanchun,Liu, Jinhua,Sun, Yipeng,Xu, Guanlong,Liu, Qinfang,Bing, Guoxia.

[7]Recombinant adenovirus expressing F and H fusion proteins of peste des petits ruminants virus induces both humoral and cell-mediated immune responses in goats. Wang, Yong,Xu, Binrui,Wang, Yong,Shi, Lijun,Li, Wenchao,Huang, Huaxin,Tao, Chunai,Cheng, Chaofei,Li, Gang,Liu, Guangqing,Chen, Zongyan,Li, Chuanfeng. 2013

[8]Enhanced immune responses in pigs by DNA vaccine coexpressing GP3 and GP5 of European type porcine reproductive and respiratory syndrome virus. Ren, Jingqiang,Jing, Jie,Xiao, Pengpeng,Jin, Ningyi,Ren, Jingqiang,Lu, Huijun,Wen, Shubo,Sun, Wenchao,Yan, Fulong,Chen, Xing,Jing, Jie,Liu, Hao,Liu, Cunxia,Xue, Fei,Xiao, Pengpeng,Xin, Shu,Jin, Ningyi,Wen, Shubo,Sun, Wenchao,Yan, Fulong,Chen, Xing,Xin, Shu,Liu, Hao.

[9]Pathological and immunological characteristics of piglets infected experimentally with a HP-PRRSV TJ strain. Li, Zhenguang,He, Yanliang,Li, Shufen,Xia, Mingqi,Wu, Hua,Li, Zhenguang,Leng, Xue,Wen, Yongjun,Wang, Fengxue,Cheng, Shipeng,Wu, Hua,Xu, Xiaoqin. 2016

[10]Effects of partially replacing dietary soybean meal or cottonseed meal with completely hydrolyzed feather meal (defatted rice bran as the carrier) on production, cytokines, adhesive gut bacteria, and disease resistance in hybrid tilapia (Oreochromis niloticus female x Oreochromis aureus male). Zhang, Zhen,Xu, Li,Liu, Wenshu,Yang, Yalin,Zhou, Zhigang,Du, Zhenyu.

[11]Genetic characterization and pathogenicity of H7N9 highly pathogenic avian influenza viruses isolated from South China in 2017. Bingbing Zhao,Wenqing Wang,Yating Song,Xiangyang Wen,Siyu Feng,Weiqiang Li,Yangbao Ding,Zuxian Chen,Zhuoliang He,Shao Wang,Peirong Jiao. 2023

[12]Integrative time series of cellular, humoral and molecular response revealed immunotoxicity of bifenthrin to Chinese rare minnow (Gobiocypris rarus) following Pseudomonas fluorescens challenge. Zhang L.,Yan S.,Hong X.,Zhao G.,Zha J.. 2023

[13]Antibody-Dependent Enhancement: ″Evil″ Antibodies Favorable for Viral Infections. Xiaoke Yang,Xin Zhang,Xiaotian Zhao,Mengqi Yuan,Kehui Zhang,Jingwen Dai,Xiangyu Guan,Hua Ji Qiu,Yongfeng Li. 2022

[14]UNC93B1 attenuates the cGAS-STING signaling pathway by targeting STING for autophagy-lysosome degradation. Zhu, Huifang,Zhang, Rongzhao,Yi, Li,Tang, Yan-Dong,Zheng, Chunfu. 2022

[15]Development and Efficacy Evaluation of a Novel Nano-Emulsion Adjuvant for a Foot-and-Mouth Disease Virus-like Particles Vaccine Based on Squalane. Xiaoni Shi,Kun Yang,Hetao Song,Zhidong Teng,Yun Zhang,Weihao Ding,Aofei Wang,Shuzhen Tan,Hu Dong,Shiqi Sun,Yonghao Hu,Huichen Guo. 2022

[16]Efficacy of a recombinant turkey herpesvirus (H9) vaccine against H9N2 avian influenza virus in chickens with maternal-derived antibodies. Xue Pan,Qinfang Liu,Shiqi Niu,Dongming Huang,Dawei Yan,Qiaoyang Teng,Xuesong Li,Nancy Beerens,Maria Forlenza,Mart C.M. de Jong,Zejun Li. 2023

[17]Tylvalosin Tartrate Improves the Health Status of Swine Herds during Immunization with Porcine Reproductive and Respiratory Syndrome Virus-Inactivated Vaccine. Zhang Q.,Cui C.,Zhang S.,Deng X.,Cai X.,Wang G.. 2023

[18]Omicron variant of SARS-CoV-2: Genomics, transmissibility, and responses to current COVID-19 vaccines. Araf, Yusha,Akter, Fariya,Tang, Yan-dong,Fatemi, Rabeya,Parvez, Md Sorwer Alam,Zheng, Chunfu,Hossain, Md Golzar. 2022

[19]Effects of dissolved oxygen on intestinal bacterial community and immunity of Atlantic salmon Salmo salar. Shihong Xu,Yanfeng Wang,Caixia Gao,Sarath Babu V,Jun Li,Qinghua Liu,Zhizhong Xiao,Yingxuan Xu,Chunyan Zhao,Li Lin,Liang Chi. 2023

[20]Evaluation of humoral and cellular immune responses induced by a cocktail of recombinant African swine fever virus antigens fused with OprI in domestic pigs. Guanglei Zhang,Wei Liu,Sicheng Yang,Shuai Song,Yunyun Ma,Guangqing Zhou,Xiaxia Liang,Chun Miao,Junhui Li,Yanhong Liu,Junjun Shao,Huiyun Chang. 2023

作者其他论文 更多>>
  • The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project

    作者:Fang, Lingzhao;Teng, Jinyan;Lin, Qing;Bai, Zhonghao;Liu, Shuli;Guan, Dailu;Li, Bingjie;Gao, Yahui;Hou, Yali;Gong, Mian;Pan, Zhangyuan;Yu, Ying;Clark, Emily L.;Smith, Jacqueline;Rawlik, Konrad;Xiang, Ruidong;Chamberlain, Amanda J.;Goddard, Michael E.;Littlejohn, Mathew;Larson, Greger;MacHugh, David E.;O'Grady, John F.;Sorensen, Peter;Sahana, Goutam;Lund, Mogens Sando;Jiang, Zhihua;Pan, Xiangchun;Gong, Wentao;Zhang, Haihan;He, Xi;Zhang, Yuebo;Gao, Ning;He, Jun;Yi, Guoqiang;Liu, Yuwen;Tang, Zhonglin;Zhao, Pengju;Zhou, Yang;Fu, Liangliang;Wang, Xiao;Hao, Dan;Liu, Lei;Chen, Siqian;Young, Robert S.;Shen, Xia;Xia, Charley;Cheng, Hao;Ma, Li;Cole, John B.;Baldwin, Ransom L.;Li, Cong-jun;Van Tassell, Curtis P.;Rosen, Benjamin D.;Bhowmik, Nayan;Lunney, Joan;Liu, Wansheng;Guan, Leluo;Zhao, Xin;Ibeagha-Awemu, Eveline M.;Luo, Yonglun;Lin, Lin;Canela-Xandri, Oriol;Derks, Martijn F. L.;Crooijmans, Richard P. M. A.;Godia, Marta;Madsen, Ol

    关键词:

  • Effects of maternal Escherichia coli lipopolysaccharide exposure on offspring: insights from lncRNA analysis in laying hens

    作者:Liu, Lei;Wang, Wei;Adetula, Adeyinka Abiola;Yan, Zhixun;Liu, Huagui;Yu, Ying;Chu, Qin

    关键词:(2-0-4)LPS maternal stimulation;Chicken;Offspring;Egg-laying rate;lncRNA

  • Genomic characteristics and epidemic trends of NADC30-like PRRSV in China

    作者:Zhang, Siyu;Xu, Hu;Guo, Zhenyang;Xiang, Lirun;Li, Chao;Gong, Bangjun;Li, Jinhao;Feng, Zixuan;Kang, Haonan;Wang, Qian;Zhou, Guohui;Leng, Chaoliang;Zhao, Kuan;Tang, Yan-Dong;Liu, Huairan;An, Tong-Qing;Cai, Xuehui;Peng, Jinmei;Tian, Zhi-Jun;Zhang, Hongliang

    关键词:NADC30-like PRRSV;Recombination patterns;Mainstream branch;Genomic characteristics;Epidemic trend

  • Multiomics analysis reveals signatures of selection and loci associated with complex traits in pigs

    作者:Liu, Lei;Yi, Guoqiang;Yao, Yilong;Liu, Yuwen;Li, Jiang;Yang, Yalan;Liu, Mei;Fang, Lingzhao;Mo, Delin;Zhang, Longchao;Liu, Yonggang;Niu, Yongchao;Wang, Liyuan;Qu, Xiaolu;Pan, Zhangyuan;Wang, Lei;Chen, Muya;Fan, Xinhao;Chen, Yun;Zhang, Yongsheng;Li, Xingzheng;Wang, Zhen;Tang, Yijie;Huang, Hetian;Yuan, Pengxiang;Liao, Yuying;Li, Xinjian;Yin, Zongjun;Liu, Di;Zhang, Dongjie;Zhou, Quanyong;Wu, Wangjun;Jiang, Jicai;Gao, Yahui;Liu, George E.;Wang, Lixian;Chen, Yaosheng;Li, Kui;Groenen, Martien A. M.;Tang, Zhonglin

    关键词:(1-1-1)epigenetics;genomic variation;pan-genome;phenotype differentiation;pig;skeletal muscle development

  • Refining Lineage Classification and Updated RFLP Patterns of PRRSV-2 Revealed Viral Spatiotemporal Distribution Characteristics in China in 1991-2023

    作者:Tian, Xiaoxiao;Wei, Ziyi;Khan, Mirwaise;Zhou, Zhi;Zhang, Jianqiang;Huang, Xinyi;Yang, Yongbo;Wang, Shujie;Wang, Haiwei;Cai, Xuehui;Meng, Fandan;An, Tongqing

    关键词:genetic diversity;lineage;PRRSV;RFLP pattern;spatiotemporal distribution

  • From hemorrhage to apoptosis: understanding the devastating impact of ASFV on piglets

    作者:Xu, Fanghua;Li, Ning;Xue, Yue;Wang, Zhenru;Fang, Zheng;An, Hui;Liu, Sidang;Weng, Changjiang;Huang, Li;Wang, Gang

    关键词:ASFV;multiple organ lesions;pathogenicity;apoptosis;piglets

  • Differential Retention and Loss of a Mycotoxin in Fungal Evolution

    作者:Chen, Lin;Yan, Ziying;Yang, Bolei;Tai, Bowen;Li, Weizhao;Li, Erfeng;Wang, Gang;Xing, Fuguo

    关键词:ochratoxin;gene cluster;evolution;degeneration