Immune responses to modified live virus vaccines developed from classical or highly pathogenic PRRSV following challenge with a highly pathogenic PRRSV strain
文献类型: 外文期刊
作者: Wang, Gang;Yu, Ying;Zhang, Chong;Tu, Yabin;Tong, Jie;Liu, Yonggang;Chang, Yafei;Jiang, Chenggang;Wang, Shujie;Cai, Xuehui;Yu, Ying;Zhou, En-Min;Zhang, Chong
作者机构:
关键词: Highly pathogenic PRRSV;PRRSV vaccine;Immune responses
期刊名称: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Modified live virus vaccines (MLVs) are used on swine farms to control porcine reproductive and respiratory syndrome virus (PRRSV). MLVs from classical PRRSV (C-PRRSV) provide some protection against emergent highly pathogenic PRRSV (HP-PRRSV). This study characterized the protective efficacy and immune response to MLVs from C-PRRSV (CH-1R) or HP-PRRSV (HuN4-F112) in a challenge using HP-PRRSV (HuN4). The outcomes were clinical signs of disease, pathological changes in the thymus and lungs, viremia, and humoral and cellular immune responses. CH-1R provided some protection against challenge with HuN4, while HuN4-F112 was protective in the HuN4 challenge. Compared to unvaccinated piglets, the vaccinated piglets had milder symptoms and fewer pathological changes in the lung and thymus. Piglets vaccinated with HuN4-F112 had higher antibody titers and lower viral loads than piglets vaccinated with CH-1R post challenge. The differences in outcome between the MLVs suggested that underlying differences in the immune responses might warrant further study. (C) 2016 Elsevier Ltd. All rights reserved.
分类号: R392
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