数字农科院2.0

Regulation of Stress Responses and Translational Control by Coronavirus

文献类型： 外文期刊

作者： Fung, To Sing;Liu, Ding Xiang;Liao, Ying

作者机构：

关键词： coronavirus;ER stress;unfolded protein response;p38;JNK;eIF2 alpha;PKR;PERK;GADD34/PP1;nsp1;translational control

期刊名称： VIRUSES-BASEL

ISSN： 1999-4915

年卷期： 2016 年 8 卷 7 期

页码：

收录情况： SCI

摘要： Similar to other viruses, coronavirus infection triggers cellular stress responses in infected host cells. The close association of coronavirus replication with the endoplasmic reticulum (ER) results in the ER stress responses, which impose a challenge to the viruses. Viruses, in turn, have come up with various mechanisms to block or subvert these responses. One of the ER stress responses is inhibition of the global protein synthesis to reduce the amount of unfolded proteins inside the ER lumen. Viruses have evolved the capacity to overcome the protein translation shutoff to ensure viral protein production. Here, we review the strategies exploited by coronavirus to modulate cellular stress response pathways. The involvement of coronavirus-induced stress responses and translational control in viral pathogenesis will also be briefly discussed.

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