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The Genomic Characterization of Equid Alphaherpesviruses: Structure, Function, and Genetic Similarity

文献类型： 外文期刊

作者： 刘荻萩;赵晓阳;王晓钧

作者机构：

关键词： comparative analysis;equid alphaherpesvirus;function;future research;genomic structure

期刊名称： Veterinary Sciences

ISSN： 2306-7381

年卷期： 2025 年 12 卷 3 期

页码：

收录情况： SCIE（2025版）

摘要： Equine herpesvirus 1 (EHV-1), EHV-4, EHV-8, and EHV-9, are classified within the subfamily Alphaherpesvirinae and are recognized as causative agents of respiratory, urogenital, and neurological disorders in horses. These viruses, collectively referred to as αEHVs, exhibits both unique and shared characteristics in terms of host interaction, pathogenesis, epidemiology, and immune evasion, which arise from both the identities and discrepancies among respective genomic homologs. The genomic architecture of αEHVs is similar to other members of the same subfamily, such as well-known HSV-1, VZV, and PRV. However, research on the molecular mechanisms underlying αEHV infection and immune response remains significantly less advanced compared to studies on human, porcine, and bovine herpesviruses. This paper systematically describes the genomic structure, function, and genetic similarities of αEHVs and conducts a comparative analysis of selected αEHVs through pairwise sequence alignments of nucleotides and amino acids. This review offers an extensive synthesis of the current understanding related to the study of αEHVs, highlighting the challenges and potential solutions for future research endeavors.

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