数字农科院2.0

Hepatic toxicity induced by exposure to glyphosate/aminomethylphosphonic acid and oxytetracycline alone or in combination in zebrafish: A novel mechanism of the gut-liver axis

文献类型： 外文期刊

作者： Junyue Zheng;Chen Wang;Miaomiao Teng;Tong Li;Jiazhen Jiang;Xiangguang Chen;Fengchang Wu

作者机构：

关键词： Aminomethylphosphonic acid;Combined toxicity;Glyphosate;Liver-gut axis;Oxytetracycline

期刊名称： Aquatic Toxicology

ISSN： 0166-445X

年卷期： 2026 年 291 卷

页码：

收录情况： SCIE（2025版）

摘要： Glyphosate (Gly) is the most commonly used herbicide in the world. Glyphosate and its main degradation product, aminomethylphosphonic acid (AMPA), are often detected in aquatic environments and may pose a threat to the health of aquatic organisms. It is well established that Gly is mainly enriched in the intestine and degraded into AMPA. However, it remains unclear whether they disrupt the gut microbiota and cause liver health effects, as well as whether they have a synergistic effect with antibiotics. We investigated herein the effects of zebrafish exposure to Gly, AMPA and oxytetracycline (OTC) alone or in combination on the gut-liver axis. Our results suggest that Gly, AMPA, and OTC induce lipid accumulation, inflammatory response and oxidative damage in the liver, which is associated with a higher Firmicutes/Bacteroidetes ratio in the intestine and a higher levels of lipopolysaccharide in serum. Compared with the single exposure groups (OTC, Gly, and AMPA), the toxic effects of the gut-liver axis were more severe in the combined exposure groups (Gly+OTC, AMPA+OTC). Our results indicate that the health risks posed by Gly, AMPA and OTC through the gut microbiota of aquatic organisms are a neglected hot spots.

分类号：

  • 相关文献

[1]Synergistic effects of combined lead and iprodione exposure on P53 signaling-mediated hepatotoxicity, enterotoxicity and transgenerational toxicity in zebrafish. Ruike Wang,Ligang Deng,Yanhua Wang,Na Liu,Menglian Yang,Jing Qiu,Chen Chen. 2025

[2]Effects of soil temperature on degradation of oxytetracycline in soils. Li Zhao-jun,Fan Fei-fei,Long Jian. 2013

[3]Uptake of oxytetracycline and its phytotoxicity to alfalfa (Medicago sativa L.). Kong, W. D.,Zhu, Y. G.,Liang, Y. C.,Zhang, J.,Smith, F. A.,Yang, A.. 2007

[4]Effects of anaerobic digestion on chlortetracycline and oxytetracycline degradation efficiency for swine manure. Yin, Fubin,Dong, Hongmin,Tao, Xiuping,Chen, Yongxing,Ji, Chao.

[5]Non-target organism species sensitivity distributions to oxytetracycline in water. Zhao Xiu-Juan,Ma Rong-Cai,Zhao Xiu-Juan,Li Zhao-Jun. 2013

[6]Effects Of Different Fertilizers On R.esidues Of Oxytetracycline And M icrobial Activity In Soil. Qin, JM, Xiong, HY, Ma, HT, Li, ZJ. 2019

[7]Fe3+ Enhanced Degradation Of Oxytetracycline I.n Water By Pseudomonas. Qi, WN, Long, J, Feng, CQ, Feng, Y, Cheng, DM, Liu, YW, Xue, JM, Li, Z. 2019

[8]Quantitative Models For Predicting Adsorption O.f Oxytetracycline, Ciprofloxacin And S ulfamerazine To Swine Manures With Contrasting Properties. Cheng, DM, Feng, Y, Liu, YW, Li, JP, Xue, JM, Li, ZJ. 2018

[9]Degradation Mechanisms Of Oxytetracycline In T.he Environment. Li, ZJ, Qi, WN, Feng, Y, Liu, YW, Shehata, E, Long, J. 2019

[10]Synergistic effects of temperature and oxytetracycline stress on continuous anaerobic digestion: Methane production, antibiotic resistance dynamics, and microbial adaptation. Huiban He,Hongyang Xu,Haoxing He,Xiaotian Chen,Weiwei Wang,Jing Yan,Hongliang Wang,Wanbin Zhu,Zongjun Cui,Xufeng Yuan. 2025

[11]Degradation of oxytetracycline in soil by a Pseudomonas strain. Xueqi Guo,Weining Qi,Yao Feng,Zhaojun Li. 2025

[12]Assessing oxytetracycline stress and antibiotic resistance gene dynamics during anaerobic treatment of cow manure. Huiban He,Xiaotian Chen,Peng Zhang,Haoxing He,Weiwei Wang,Boting Wen,Zongjun Cui,Xufeng Yuan. 2025

[13]Extended biotic ligand model for predicting combined Cu-Zn toxicity to wheat (Triticum aestivum L.): Incorporating the effects of concentration ratio, major cations and pH. Wang, Xuedong,Ji, Dongxue,Chen, Xiaolin,Li, Xiaoxiu,Ma, Yibing,Ma, Yibing,Yang, Junxing.

[14]Joint acute toxicity of the herbicide butachlor and three insecticides to the terrestrial earthworm, Eisenia fetida. Wang, Yanhua,Cang, Tao,Yu, Ruixian,Wu, Shenggan,Liu, Xinju,Wang, Qiang,Cai, Leiming,Chen, Chen.

[15]Assessing joint toxicity of four organophosphate and carbamate insecticides in common carp (Cyprinus carpio) using acetylcholinesterase activity as an endpoint. Wang, Yanhua,Zhao, Xueping,Wang, Qiang,Chen, Chen,Qian, Yongzhong.

[16]The combined toxicity assessment of carp (Cyprinus carpio) acetylcholinesterase activity by binary mixtures of chlorpyrifos and four other insecticides. Chen, Chen,Qian, Yongzhong,Wang, Yanhua,Zhao, Xueping,Wang, Qiang. 2014

[17]Extended Biotic Ligand Model For P.redicting Combined Cu-Zn Toxicity T o Wheat (Triticum Aestivum L.): Incorporating The Effects Of Concentration Ratio, Major Cations And Ph. Wang, XD, Ji, DX, Chen, XL, Ma, YB, Yang, JX, Ma, JX, Li, XX. 2017

[18]Joint Acute And Endocrine Disruptive T.oxicities Of Malathion, Cypermethrin A nd Prochloraz To Embryo-Larval Zebrafish, Darzio Rerio. Guo, DM, Wang, YH, Qian, YZ, Chen, C, Jiao, BN, Cai, LM, Wang, Q. 2017

[19]Variations of enzymatic activity and gene expression in zebrafish (Danio rerio) embryos co-exposed to zearalenone and fumonisin B1. Guiling Yang,Yanhua Wang,Tiancai Wang,Dou Wang,Hongbiao Weng,Qiang Wang,Chen Chen. 2021

[20]Insights into the combined toxic impacts of phoxim and deltamethrin on the embryo-larval stage of zebrafish (Danio rerio). Lv, Lu,Gao, Zhongwen,Mao, Liangang,Liu, Xinju,Wang, Qiang,Shen, Weifeng,Wang, Yanhua. 2022

作者其他论文 更多>>