文献类型： 外文期刊
作者： Cao, Yufan;Qiao, Hongbin;Shi, Yanli;Han, Yu;Liu, Jinming;Li, Hao;Lu, Ke;Lin, Jiaojiao;Jin, Yamei;Lin, Jiaojiao
作者机构：
期刊名称： BIOMED RESEARCH INTERNATIONAL
ISSN： 2314-6133
年卷期： 2016 年
页码：
收录情况： SCI
摘要： Schistosomiasis is a neglected tropical disease of humans, and it is considered to be the second most devastating parasitic disease after malaria. Eggs produced by normally developed female worms are important in the transmission of the parasite, and they responsible for the pathogenesis of schistosomiasis. The tumor suppressor gene lethal giant larvae (lgl) has an essential function in establishing apical-basal cell polarity, cell proliferation, differentiation, and tissue organization. In our earlier study, downregulation of the lgl gene induced a significant reduction in the egg hatching rate of Schistosoma japonicum (Sj) eggs. In this study, the Sjlgl gene was used as a vaccine candidate against schistosomiasis, and vaccination achieved and maintained a stable reduction of the egg hatching rate, which is consistent with previous studies, in addition to reducing the wormburden and liver egg burden in some trials.
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