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The Differential Expression of Immune Genes between Water Buffalo and Yellow Cattle Determines Species-Specific Susceptibility to Schistosoma japonicum Infection

文献类型： 外文期刊

作者： Yang, Jianmei;Fu, Zhiqiang;Hong, Yang;Jin, Yamei;Zhu, Chuangang;Li, Hao;Lu, Ke;Shi, Yaojun;Yuan, Chunxiu;Cheng, Guofeng;Feng, Xingang;Liu, Jinming;Lin, Jiaojiao;Wu, Haiwei;Lin, Jiaojiao

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期刊名称： PLOS ONE

ISSN： 1932-6203

年卷期： 2015 年 10 卷 6 期

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收录情况： SCI

摘要： Water buffalo are less susceptible to Schistosoma japonicum infection than yellow cattle. The factors that affect such differences in susceptibility remain unknown. A Bos taurus genome-wide gene chip was used to analyze gene expression profiles in the peripheral blood of water buffalo and yellow cattle pre- and post-infection with S. japonicum. This study showed that most of the identified differentially expressed genes(DEGs) between water buffalo and yellow cattle pre- and post-infection were involved in immune-related processes, and the expression level of immune genes was lower in water buffalo. The unique DEGs (390) in yellow cattle were mainly associated with inflammation pathways, while the unique DEGs (2,114) in water buffalo were mainly associated with immune-related factors. The 83 common DEGs may be the essential response genes during S. japonicum infection, the highest two gene ontology (GO) functions were associated with the regulation of fibrinolysis. The pathway enrichment analysis showed that the DEGs constituted similar immune-related pathways pre- and post-infection between the two hosts. This first analysis of the transcriptional profiles of natural hosts has enabled us to gain new insights into the mechanisms that govern their susceptibility or resistance to S. japonicum infections.

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