数字农科院2.0

Synthesis and Bioactivity Studies of 2,3-Disubstituted Quinazolin-4(3H)-one

文献类型： 外文期刊

作者： Liu Kechang;Wang Yi;Zhang Hao;Liu Ruiquan;Li Qibo;Liu Shangzhong;Wang Qingmin;Li Yongqiang;Rui Changhui

作者机构：

关键词： 2,3-disubstituted quinazolin-4(3H)-ones;synthesis;bioactivities;crystal structure

期刊名称： CHINESE JOURNAL OF ORGANIC CHEMISTRY

ISSN： 0253-2786

年卷期： 2014 年 34 卷 3 期

页码：

收录情况： SCI

摘要： In this research, a series of new 2,3-disubstituted quinazolin-4(3H)-ones were designed and synthesized. The influence of common drying agents on the formation of 2,3-disubstituted quinazolin-4(3H)-ones was investigated and firstly reported. It is found that the anhydrous magnesium sulfate can increase the yield of 2,3-disubstituted quinazolin-4(3H)-ones significantly. The structures of new compounds were all confirmed via H-1 NMR, C-13 NMR and HRMS. At the same time, the crystal structure of 3-(benzylamino)-6-chloro-8-methyl-2-neopentyl-quinazolin-4(3H)-one was firstly reported. The results of bioactivity assay showed that some of these new compounds have some control effects on wheat powdery mildew (Blumeria graminis) in vivo at a concentration of 200 mg/L.

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