数字农科院2.0

Integrated Multi-Omics of the Longissimus Dorsal Muscle Transcriptomics and Metabolomics Reveals Intramuscular Fat Accumulation Mechanism with Diet Energy Differences in Yaks

文献类型： 外文期刊

作者： Jingying Deng;Pengjia Bao;Ning Li;Siyuan Kong;Tong Wang;Minghao Zhang;Qinran Yu;Xinyu Cao;Jianlei Jia;Ping Yan

作者机构：

关键词： （0-1-4）intramuscular fat deposition;lipid metabolomics;longissimus dorsal muscle;transcriptomics;yak

期刊名称： Biomolecules

ISSN： 2218-273X

年卷期： 2025 年 15 卷 7 期

页码：

收录情况： SCIE（2025版）

摘要： IMF (intramuscular fat, IMF), as a key index for evaluating meat quality traits (shear force and cooking loss, etc.), and its deposition process are jointly regulated by nutritional and genetic factors. In this study, we analyzed the molecular regulation mechanism of IMF deposition in the LD (longissimus dorsal muscle, LD) by dietary energy level in Pamir yaks. Meat quality assessment showed that the meat quality of the High-energy diet group (1.53 MJ/Kg, G) and the Medium-energy diet group (1.38 MJ/Kg, Z) were significantly improved compared with that of the Low-energy diet group (0.75 MJ/Kg, C), in which IMF content in the LD of yaks in G group was significantly higher (p < 0.05) compared with Z and C groups. Further analysis by combined transcriptomics and lipid metabolomics revealed that the differences in IMF deposition mainly originated from the metabolism of lipids, such as TG (triglycerides, TG), PS (phosphatidylserine, PS), and LPC (lysophosphatidylcholine, LPC), and were influenced by SFRP4, FABP4, GADD45A, PDGFRA, RBP4, and DGAT2 genes, further confirming the importance of lipid–gene interactions in IMF deposition. This study reveals the energy-dependent epigenetic regulatory mechanism of IMF deposition in plateau ruminants, which provides molecular targets for optimizing yak nutritional strategies and quality meat production, while having important theoretical and practical value for the sustainable development of livestock husbandry on the Tibetan Plateau.

分类号：

  • 相关文献

[1]Transcriptomics and Lipid Metabolomics Analysis of Subcutaneous, Visceral, and Abdominal Adipose Tissues of Beef Cattle. Lili Du,Tianpeng Chang,Bingxing An,Mang Liang,Tianyu Deng,Keanning Li,Sheng Cao,Yueying Du,Xue Gao,Lingyang Xu,Lupei Zhang,Junya Li,Huijiang Gao. 2023

[2]A comprehensive study on the longissius dorsi muscle of Ashdan yaks under different feeding regimes based on transcriptomic and metabolomic analyses. Wang, Tong,Ma, Xiaoming,Zheng, Qingbo,Ma, Chaofan,Zhang, Zhilong,Pan, Heping,Guo, Xian,Wu, Xiaoyun,Chu, Min,Liang, Chunnian,Yan, Ping. 2024

[3]The effects of different doses of compound enzyme preparations on the production performance, meat quality and rumen microorganisms of yak were studied by metagenomics and transcriptomics. Chenyang Zhang,Yong Fu La,Xiaoming Ma,Pingcuo Zhandui,Xiaoyun Wu,Xian Guo,Ping Yan,Luosan Dunzhu,Chunnian Liang. 2024

[4]“大通”牦牛Lfcin基因克隆及生物信息学分析(英文). 裴杰,阎萍,姬国红,冯瑞林,梁春年,郭宪,曾玉峰,包鹏甲,褚敏. 2009

[5]The Study Of The Response Of Fat Metabolism To Long-Term Energy Stress Based On Serum, Fatty Acid And Transcriptome Profiles In Yaks. Pei, Jie,Bao, Pengjia,Wu, Xiaoyun,Liang, Chunnian,Yao, Xixi,Guo, Xian,Kalwar, Qudratullah,Guo, Xian,Chu, Min,Bao, Pengjia,Yan, Ping,Pei, Jie,Xiong, Lin,Xiong, Lin,Wu, Xiaoyun,Yao, Xixi,Chu, Min,Yan, Ping,Liang, Chunnian. 2020

[6]Dietary Energy Levels Affect Growth P.erformance Through Growth Hormone A nd Insulin-Like Growth Factor 1 In Yak (Bos Grunniens). Yang, Chao,Yan, Ping,Yang, Chao,Ahmad, Anum Ali,Bao, Pengjia,Zhang, Jianbo,Long, Ruijun,Ding, Xuezhi,Guo, Xian. 2019

[7]The Breed and Sex Effect on the Carcass Size Performance and Meat Quality of Yak in Different Muscles. Zhang, Li,Yu, Qunli,Wang, Li,Zhou, Yuchun,Li, Yongpeng,Sun, Baozhong,Xie, Peng,Li, Haipeng,Huang, Caixia,Liu, Xuan,Ji, Qiumei. 2016

[8]Conserved Exon 2 but a Highly Polymorphic 5 '-UTR of Tyrosinase Gene in Tianzhu White Yak (Bos grunniens). Zhang, H.,Han, J. L.,Zhang, H.,Luo, Y. Z.,An, T. W.,He, J. W.,Han, J. L.. 2012

[9]Genetic polymorphisms of the IGF-II gene intron 8 coding region and its association with growth and carcass traits in yak. Zeng, Y. F.,Yu, S. J.,Zeng, Y. F.,Ding, X. Z.,Cheng, S. R.. 2013

[10]Physiological insight into the high-altitude adaptations in domesticated yaks (Bos grunniens) along the Qinghai-Tibetan Plateau altitudinal gradient. Ding, X. Z.,Liang, C. N.,Guo, X.,Wu, X. Y.,Wang, H. B.,Yan, P.,Ding, X. Z.,Liang, C. N.,Guo, X.,Wu, X. Y.,Wang, H. B.,Yan, P.,Johnson, K. A.. 2014

[11]Genetic variation in the kappa-casein gene (CSN3) of Chinese yak (Bos grunniens) and phylogenetic analysis of CSN3 sequences in the genus Bos. Prinzenberg, E. -M.,Erhardt, G.,Jianlin, H.,Jianlin, H.. 2008

[12]PPAR alpha signal pathway gene expression is associated with fatty acid content in yak and cattle longissimus dorsi muscle. Qin, W.,Liang, C. N.,Guo, X.,Chu, M.,Pei, J.,Bao, P. J.,Wu, X. Y.,Li, T. K.,Yan, P.. 2015

[13]Comparative proteomics of milk fat globule membrane in different species reveals variations in lactation and nutrition. Lu, Jing,Zhang, Weiqing,Liu, Lu,Pang, Xiaoyang,Zhang, Shuwen,Lv, Jiaping,Wang, Xinyu,Wang, Xinyu.

[14]Association between single-nucleotide polymorphisms of fatty acid synthase gene and meat quality traits in Datong Yak (Bos grunniens). Chu, M.,Wu, X. Y.,Guo, X.,Pei, J.,Liang, C. N.,Ding, X. Z.,Bao, P. J.,Yan, P.,Chu, M.,Wu, X. Y.,Guo, X.,Pei, J.,Liang, C. N.,Ding, X. Z.,Bao, P. J.,Yan, P.,Jiao, F.,Fang, H. T.. 2015

[15]Molecular Cloning And Characterization Of Sycp3 And Tseg2 Genes In The Testicles Of Sexually Mature And Immature Yak. Ma, Xiaoming,Ahmad, Anum Ali,Yan, Ping,Zhang, Renzheng,Ahmad, Anum Ali,Chu, Min,Xie, Jianpeng,Ding, Xuezhi,Kalwar, Qudratullah,Ma, Fulong,Wu, Xiaoyun,Bao, Pengjia,Kalwar, Qudratullah. 2019

[16]Association of novel single-nucleotide polymorphisms of the vascular endothelial growth factor-A gene with high-altitude adaptation in yak (Bos grunniens). Wu, X. Y.,Liang, C. N.,Ding, X. Z.,Guo, X.,Bao, P. J.,Chu, M.,Liu, W. B.,Yan, P.,Wu, X. Y.,Liang, C. N.,Ding, X. Z.,Guo, X.,Bao, P. J.,Chu, M.,Liu, W. B.,Yan, P.. 2013

[17]Serological survey of Toxoplasma gondii in Tibetan mastiffs (Canis lupus familiaris) and yaks (Bos grunniens) in Qinghai, China. Wang, Meng,Wang, Yan-hua,Ye, Qiang,Meng, Peng,Yin, Hong,Zhang, De-lin. 2012

[18]Foot-and-mouth disease virus carrier status in Bos grunniens yaks. Chang, Huiyun,Ma, Yanbin,Lin, Tong,Cong, Guozheng,Du, Junzheng,Ma, Jinling. 2013

[19]Molecular investigation of bovine viral diarrhea virus infection in yaks (Bos gruniens) from Qinghai, China. Gong, Xiaowei,Zheng, Fuying,Chen, Qiwei,Li, Zhaocai,Cao, Xiaoan,Yin, Hong,Zhou, Jizhang,Cai, Xuepeng. 2014

[20]Efficiency of in vitro embryo production of yak (Bos grunniens) cultured in different maturation and culture conditions. Guo, Xian,Ding, Xuezhi,Pei, Jie,Bao, Pengjia,Liang, Chunnian,Chu, Min,Yan, Ping,Guo, Xian,Ding, Xuezhi,Pei, Jie,Bao, Pengjia,Liang, Chunnian,Chu, Min,Yan, Ping. 2012

作者其他论文 更多>>