数字农科院2.0

The combined toxicity assessment of carp (Cyprinus carpio) acetylcholinesterase activity by binary mixtures of chlorpyrifos and four other insecticides

文献类型： 外文期刊

作者： Chen, Chen;Qian, Yongzhong;Wang, Yanhua;Zhao, Xueping;Wang, Qiang

作者机构：

关键词： Organophosphates;Carbamates;Cyprinus carpio;Concentration addition;Isobole;Combined toxicity

期刊名称： ECOTOXICOLOGY

ISSN： 0963-9292

年卷期： 2014 年 23 卷 2 期

页码：

收录情况： SCI

摘要： Mixtures of organophosphate (OP) and carbamate (CB) insecticides are commonly detected in freshwater habitats. These insecticides inhibit the activity of acetylcholinesterase (AChE) and have potential to interfere with behaviors that may be essential for survival of species. Although the effects of individual anticholinesterase insecticides on aquatic species have been studied for decades, the combined toxicity of mixtures is still poorly understood. In the present study, we assessed whether pesticides in a mixture act in isolation (resulting in additive AChE inhibition) or whether components interact to produce either antagonistic or synergistic toxicity. Brain AChE inhibition in carp (Cyprinus carpio L.) exposed to a series of concentrations of the OP (chlorpyrifos, malathion and triazophos) as well as the CB (fenobucarb and carbosulfan) were measured. The concentration addition (CA) model and the isobole method were used to determine whether toxicological responses to binary mixtures of pesticides. In 50:50 % effect mixtures, the observed combined toxicity of chlorpyrifos and malathion was significantly higher than observed and was considered as synergistic. For equivalent dose mixtures, when chlorpyrifos mixed with fenobucarb or malathion, the observed toxicities were significantly higher than predicted, suggesting synergistic joint actions. The rest five binary combinations exhibited concentration additive or slight antagonistic joint actions. The CA model and the isobole method provided estimates of mixture toxicity that did not markedly underestimate the measured toxicity, therefore these methods are suitable to use in ecological risk assessments of pesticide mixtures.

分类号：

  • 相关文献

[1]Assessing joint toxicity of four organophosphate and carbamate insecticides in common carp (Cyprinus carpio) using acetylcholinesterase activity as an endpoint. Wang, Yanhua,Zhao, Xueping,Wang, Qiang,Chen, Chen,Qian, Yongzhong.

[2]Single and joint toxicity of polymethyl methacrylate microplastics and As (V) on rapeseed (Brassia campestris L.). Ruyin Dong,Rongle Liu,Yingming Xu,Weitao Liu,Lin Wang,Xuefeng Liang,Qingqing Huang,Yuebing Sun. 2022

[3]The degradation effects of a Pseudomonas hydrolase OPHC2 to organophosphorus insecticides. Wang, Jin-Fang,Gao, Ming-Hui,Pan, Can-Ping,Wu, Ning-Feng.

[4]Rapid Colorimetric Determination Of The P.esticides Carbofuran And Dichlorvos B y Exploiting Their Inhibitory Effect On The Aggregation Of Peroxidase-Mimicking Platinum Nanoparticles. Cao, J, Wang, M, She, YX, Abd El-Aty, AM, Hacimuftuoglu, A, Wang, J, Yan, MM, Hong, SH, Lao, SB, Wang, YL. 2019

[5]Effects of dietary microencapsulated sodium butyrate on growth, intestinal mucosal morphology, immune response and adhesive bacteria in juvenile common carp (Cyprinus carpio) pre-fed with or without oxidised oil. Liu, Wenshu,Zhou, Zhigang,Yang, Yanou,Zhang, Jianli,Gatlin, Delbert M.,Ringo, Einar.

[6]The positive effects of postbiotic (SWF concentration®) supplemented diet on skin mucus, liver, gut health, the structure and function of gut microbiota of common carp (Cyprinus carpio) fed with high-fat diet. Zhe Yu,Qiang Hao,Shu Bin Liu,Qing Shuang Zhang,Xing Yu Chen,Sheng Hui Li,Chao Ran,Ya Lin Yang,Tsegay Teame,Zhen Zhang,Zhi Gang Zhou. 2023

[7]Long-Term Exposure to Phenanthrene Induced Gene Expressions and Enzyme Activities of Cyprinus carpio below the Safe Concentration. Xin Kang,Dongpeng Li,Xiaoxiang Zhao,Yanfeng Lv,Xi Chen,Xinshan Song,Xiangyu Liu,Chengrong Chen,Xin Cao. 2022

[8]The effect of dietary supplementation with Lactobacillus rhamnosus GCC-3 fermentation product on gut and liver health of common carp (Cyprinus carpio). Chen J.,Zhang J.,Xie M.,Hao Q.,Liang H.,Li M.,Zhou W.,Zhang Z.,Ran C.,Zhou Z.. 2024

[9]Extended biotic ligand model for predicting combined Cu-Zn toxicity to wheat (Triticum aestivum L.): Incorporating the effects of concentration ratio, major cations and pH. Wang, Xuedong,Ji, Dongxue,Chen, Xiaolin,Li, Xiaoxiu,Ma, Yibing,Ma, Yibing,Yang, Junxing.

[10]Joint acute toxicity of the herbicide butachlor and three insecticides to the terrestrial earthworm, Eisenia fetida. Wang, Yanhua,Cang, Tao,Yu, Ruixian,Wu, Shenggan,Liu, Xinju,Wang, Qiang,Cai, Leiming,Chen, Chen.

[11]Extended Biotic Ligand Model For P.redicting Combined Cu-Zn Toxicity T o Wheat (Triticum Aestivum L.): Incorporating The Effects Of Concentration Ratio, Major Cations And Ph. Wang, XD, Ji, DX, Chen, XL, Ma, YB, Yang, JX, Ma, JX, Li, XX. 2017

[12]Joint Acute And Endocrine Disruptive T.oxicities Of Malathion, Cypermethrin A nd Prochloraz To Embryo-Larval Zebrafish, Darzio Rerio. Guo, DM, Wang, YH, Qian, YZ, Chen, C, Jiao, BN, Cai, LM, Wang, Q. 2017

[13]Variations of enzymatic activity and gene expression in zebrafish (Danio rerio) embryos co-exposed to zearalenone and fumonisin B1. Guiling Yang,Yanhua Wang,Tiancai Wang,Dou Wang,Hongbiao Weng,Qiang Wang,Chen Chen. 2021

[14]Insights into the combined toxic impacts of phoxim and deltamethrin on the embryo-larval stage of zebrafish (Danio rerio). Lv, Lu,Gao, Zhongwen,Mao, Liangang,Liu, Xinju,Wang, Qiang,Shen, Weifeng,Wang, Yanhua. 2022

[15]Mixture toxicity of pyraclostrobine and metiram to the zebrafish (Danio rerio) and its potential mechanism. Wang, Yanhua,Gao, Zhongwen,Liu, Chuande,Mao, Liangang,Liu, Xinju,Ren, Jindong,Lu, Zeqi,Yao, Jie,Liu, Xuan. 2023

[16]Combined Toxicity Of Imidacloprid, Acetochlor, And Tebuconazole To Zebrafish (Danio Rerio): Acute Toxicity And Hepatotoxicity Assessment. Chang, YM, Mao, LG, Zhang, L, Zhang, YN, Jiang, HY. 2020

[17]Evaluating the Impact of Individual and Combined Toxicity of Imidacloprid, Cycloxaprid, and Tebuconazole on Daphnia magna. Yanli Man,Tian Sun,Chi Wu,Xingang Liu,Mingyuan He. 2023

[18]Transgenerational combined toxicity effects of neonicotinoids and triazole pesticides at environmentally relevant concentrations on D. magna: From individual to population level. Chi Wu,Kai He,Huizhen Li,Lan Zhang,Liangang Mao,Lizhen Zhu,Jinhua Jiang,Xingang Liu. 2025

[19]Microplastics aggravate the adverse effects of methylmercury than inorganic mercury on zebrafish (Danio rerio). Yajie Lei,Xue Li,Xuefei Mao. 2025

[20]Perfluorooctane sulfonate (PFOS) and benzo[a]pyrene (BaP) synergistically induce neurotoxicity in C6 rat glioma cells via the activation of neurotransmitter and Cyp1a1-mediated steroid hormone synthesis pathways. Yu Shun Lu,Ju Chen,Xiao Rong He,Shang Lin Yang,Bing Jie Ma,Jiang Yu,Jing Qiu,Yong Zhong Qian,Yan Yang Xu. 2024

作者其他论文 更多>>