数字农科院2.0

Safety evaluation of daidzein in laying hens: Part I. Effects on laying performance, clinical blood parameters, and organs development

文献类型： 外文期刊

作者： Shi, S. R.;Gu, H.;Chang, L. L.;Tong, H. B.;Zou, J. M.;Gu, H.;Wang, Z. Y.

作者机构：

关键词： Daidzein;Laying hens;Safety evaluation;Laying performance;Clinical blood parameters;Organs development

期刊名称： FOOD AND CHEMICAL TOXICOLOGY

ISSN： 0278-6915

年卷期： 2013 年 55 卷

页码：

收录情况： SCI

摘要： Daidzein, an estrogen-like product, becomes increasingly popular as a dietary supplement, particularly for postpeak-estrus animals seeking a safe natural alternative to play a role of estrogen. However, there is little available safety data of it for raisers and consumers. A subchronic laying hen safety study was conducted to examine if the high-dose daidzein could affect the safety of hens selves, including laying performance, clinical blood parameters and organs development. Seven hundred and sixty-eight 56-week-old Hyline Brown were randomly assigned to 4 groups with 8 replicates of 24 birds each and 3 weeks later fed diets supplemented with 0, 10, 50 and 100 mg of daidzein/kg for 12 weeks. The mortality was significantly decreased (P < 0.05). No treatment related adverse clinical signs were observed. Mean egg production, egg mass and feed conversion of whole experiment period was significantly influenced by dietary daidzein supplement (Pc 0.05), showing significant quadratic response to increasing dietary daidzein supplement (P = 0.029, P = 0.003 and P = 0.019, respectively). There was no statistically significant changes in haematology (P > 0.05). In clinical chemistry parameters, total protein, total cholesterol, calcium and phosphorus were significantly affected by dietary daidzein supplement (P < 0.05). The no observed adverse effect level (NOAEL) is considered to be 50 mg/kg. (C) 2013 Elsevier Ltd. All rights reserved.

分类号：

  • 相关文献

[1]Effects of Arginine Supplementation on Organ Development, Egg Quality, Serum Biochemical parameters, and Immune Status of Laying Hens. Yang, H.,Ju, X.,Wang, Z.,Yang, Z.,Wang, W.,Lu, J.. 2016

[2]Safety evaluation of daidzein in laying hens: Effects on laying performance, hatchability, egg quality, clinical blood parameters, and organ development. Lu, J.,Qu, L.,Shen, M. M.,Li, S. M.,Dou, T. C.,Hu, Y. P.,Wang, K. H..

[3]Safety evaluation of daidzein in laying hens: Part II. Effects on calcium-related metabolism. Gu, H.,Shi, S. R.,Chang, L. L.,Tong, H. B.,Zou, J. M.,Gu, H.,Wang, Z. Y.. 2013

[4]Effects of daidzein on egg production and gonadotropin related gene expression in the ovary and follicles of laying hens. Shen, Yiru,Wang, Qiang,Shao, Dan,Zhao, Xu,Hu, Yan,Tong, H. B.,Shi, S. R.,Shi, S. R..

[5]Effects of High-Dose Daidzein on Laying Performance, Egg Quality and Anticoddation in Laying Hens. Cai, Juan,Shi, Shourong,Tong, Haibing,Gu, Huan. 2013

[6]Effect of dietary daidzein supplementation on reproductive performance, egg quality and bone mineralization in laying hens at first-cycle of production via reproductive-growth axis. Uchechukwu Edna Obianwuna,Xinyu Chang,Rupeng Wu,Hai jun Zhang,Kai Qiu,Shu geng Wu. 2024

[7]Dissipation, residues, and safety evaluation of trifloxystrobin and tebuconazole on ginseng and soil. Wang, Yan,Gao, Jie,Liu, Chang,Wang, Chunwei,Cui, Lili,Li, Aijun.

[8]Safety evaluation of phytosterols in laying hens: Effects on laying performance, clinical blood parameters, and organ development. Shi, S. R.,Shen, Y. R.,Chang, L. L.,Bo, Z.,Tong, H. B.,Zou, J. M.,Zhou, C. J.,Wang, Z. Y.. 2014

[9]Agricultural GMO safety administration in China. Kou Jian-ping,Zhang Xian-fa,Tang Qiao-ling. 2015

[10]Risk assessment of predatory lady beetle Propylea japonica's multi-generational exposure to three non-insecticidal agrochemicals. Guofeng Chang,Hui Xue,Jichao Ji,Li Wang,Xiangzhen Zhu,Kaixin Zhang,Dongyang Li,Xueke Gao,Lin Niu,Mengxue Gao,Junyu Luo,Jinjie Cui. 2023

[11]Safety study of fluralaner solution on poultry red mite: A clinical study screening of the optimal dose and focusing on hepatic and renal parameters. Tingting Sun,Hao Wu,Jing Liu,Lin Jiang,Xinyu Wang,Fei Xu,Xiubo Li. 2025

[12]Identification and Genetic Characterization of a Strain of African Horse Sickness Virus Serotype 1 and Its Safety Evaluation in a Mouse Model. Min Zhang,Xue Feng Wang,Si Fan Guo,Lei Wang,Bo Fan Fu,Jing Wen Wang,Ya Fen Song,Xiao Yue Yang,Si Yuan Hao,Qian Yi Zhang,Bing Zhang,Cheng Huai Yang. 2025

[13]Screening of Positive Controls for Environmental Safety Assessment of RNAi Products. Ding, Kaixuan,Yang, Xiaowei,Zhou, Qinli,Chen, Geng,Chen, Fengping,Tan, Yao,Li, Jing,Han, Lanzhi. 2025

[14]A Mixture Of Daidzein And C.hinese Herbs Increases Egg P roduction And Eggshell Strength As Well As Blood Plasma Ca, P, Antioxidative Enzymes, And Luteinizing Hormone Levels In Post-Peak, Brown. Shao, D.,Shao, D.,Sheng, Z. W.,Xiao, Y. Q.,Xiao, Y. Q.,Wang, Q.,Shi, S. R.,Wang, Q.,Shi, S. R.,Shi, S. R.,Sheng, Z. W.. 2019

[15]Safety Evaluation Of Daidzein In L.aying Hens: Effects On L aying Performance, Hatchability, Egg Quality, Clinical Blood Parameters, And Organ Development. Qu, L.,Shen, M. M.,Wang, K. H.,Lu, J.,Dou, T. C.,Hu, Y. P.,Li, S. M.. 2017

[16]Analysis of Two Bradyrhizobium japonicum Strains with Different Symbiotic Matching for Nodulation by Primary Proteomic. Guan Da-wei,Ma Ming-chao,Ma Zhong-yu,Jiang Xin,Li Li,Cao Feng-ming,Shen De-long,Chen Hui-jun,Li Jun,Guan Da-wei,Jiang Xin,Li Jun. 2012

[17]Transcriptome Sequencing Reveals Genetic Mechanisms Of Reproduction Performance Stimulated By Dietary Daidzein In Laying Breeder Hens. Shi, Shourong,Wang, Qiang,Tong, Haibing,Shi, Shourong,Shao, Dan,Hu, Yan,Wang, Qiang,Tong, Haibing,Shi, Shourong,Shao, Dan,Hu, Yan. 2020

[18]Proteomic Study on Two Bradyrhizobium japonicum Strains with Different Competitivenesses for Nodulation. Li Jun,Xiao Wen-li,Ma Ming-chao,Guan Da-wei,Jiang Xin,Cao Feng-ming,Shen De-long,Chen Hui-jun,Li Li,Li Jun,Xiao Wen-li,Guan Da-wei,Jiang Xin. 2011

[19]A tolerance and safety assessment of daidzein in a female fish (Carassius auratus gibelio). Li, Yanxian,Zhang, Yanjiao,Mai, Kangsen,Hu, Haibin,Liu, Jintao,Li, Yanxian,Zhang, Yanjiao,Mai, Kangsen,Hu, Haibin,Liu, Jintao,Yu, Huanhuan,Xue, Min.

[20]Effects of daidzein on antioxidant capacity in weaned pigs and IPEC-J2 cells. Yanpin Li,Xianren Jiang,Long Cai,Yanli Zhang,Hongbiao Ding,Jingdong Yin,Xilong Li. 2022

作者其他论文 更多>>