数字农科院2.0

Synthesis and Fungicidal Activities of Nucleoside Compounds Containing Substituted Benzoyl Thiourea

文献类型： 外文期刊

作者： Zhang Jiwei;Li Ying;Xu Yan;Li Hui;Yang Xinling;Ling Yun;Yuan Huizhu

作者机构：

关键词： chitin;polyoxins;uridine;thiourea;fungicidal activity

期刊名称： CHINESE JOURNAL OF ORGANIC CHEMISTRY

ISSN： 0253-2786

年卷期： 2012 年 32 卷 5 期

页码：

收录情况： SCI

摘要： To find new fungicidal lead compounds, based on the catalytic mechanism of chitin synthase, a series of novel nucleoside compounds containing thiourea were designed via the method of linking active sub-structures, in which the thiourea with high fungicidal activity was combined to the uridine part of polyoxins and nikkomycins. The target compounds were synthesized from uridine in 5 steps. Their structures were confirmed by IR, H-1 NMR spectra and elemental analysis. The preliminary bioassay results indicated that some compounds showed obvious inhibition effects against Phomopsisasparagi bubak, especially, and the fungicidal activity of 6m (97.2%) at 50 mu g/mL is similar to that (100%) of polyoxin B.

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