数字农科院2.0

Bioactive Peptides from Low Denatured Peanut Dregs: Production and Antihypertensive Activity

文献类型： 外文期刊

作者： Zhang Yuhao;Ma Liang;Wang Qiang

作者机构：

关键词： Component;formatting;Low denatured peanut dregs;Peanut oligopeptide;ACE inhibitory activity;Competitive inhibitor;Antihypertensive

期刊名称： MATERIALS FOR ENVIRONMENTAL PROTECTION AND ENERGY APPLICATION, PTS 1 AND 2

ISSN： 1022-6680

年卷期： 2012 年 343-344 卷

页码：

收录情况： SCI

摘要： Hydrolysates of peanut protein from low denatured peanut dregs, which inhibit the angiotensin I converting enzyme (ACE) were prepared by enzymic hydrolysis with Alcalase and N120p that are two proteases available for industrial use. Combination of Alcalase and N120p hydrolyzed peanut proteins most efficiently and the hydrolysates showed the most high activity (IC50=0.548 mg/ml). Sequential ultrafiltration of the hydrolysates with MW cut-off 10, 5 and 1KD resulted in increased activity of each filtrate up to IC50 of 0.255 mg/ml. Sephadex G-15 gel chromatography of the oligopeptides below MW 1KD eluted a peptide fraction of the most potent activity (IC50=0.091 mg/ml). the oligopeptide below MW 1 KD competitively inhibited ACE and it was evaluated for antihypertensive effect in spontaneously hypertensive rats (SHRs) following oral administration. Systolic blood pressure (SBP) significantly decreased after peptide ingestion and higher dose of peanut oligopeptides could not induce occurrence of low blood pressure.

分类号：

  • 相关文献

[1]Evaluation of the nutritional, in vitro protein digestive and bioactive characteristics of a quinoa-based protein beverage. Mengzhuo Li,Man Li Zhu,Junjuan Wang,Liang Zou,Xiaoyan Zhao,Dan Wang,Yuanyan Zhao,Zhiwen Ge,Lizhen Zhang,Peiyou Qin. 2025

[2]Effects of Long-Term Application of Sulfur-Containing and Chloride-Containing Chemical Fertilizers on Rice Yield and Its Components. Shen Pu,Li Dong-chu,Gao Ju-sheng,Xu Ming-gang,Wang Bo-ren,Hou Xiao-juan. 2011

[3]The effect of ultrasonic-assisted enzymes extraction on antioxidant polysaccharide activity in dandelion. Shuang Ni,Haolan Zhao,Shaohua Yang,Kai Cui. 2025

[4]Effect of radio frequency pretreatment on the component of rapeseed and its product: Comparative study with microwave pretreatment under different oil extraction methods. Weijun Wang,Chang Zheng,Bo Yang,Wenlin Li,Fenghong Huang,Changsheng Liu. 2025

作者其他论文 更多>>