数字农科院2.0

Simultaneous Determination of 5 Peptide Antibiotics in Bovine Milk Samples by Liquid Chromatography-Tandem Mass Spectrometry

文献类型： 外文期刊

作者： Liu Jia-Jia;Jin Fen;She Yong-Xin;Liu Hong-Bin;Shi Xiao-Mei;Wang Miao;Wang Jing;Xu Si-Yuan

作者机构：

关键词： High performance liquid chromatography tandem mass spectrometry;Milk;Peptide antibiotics;Residue

期刊名称： CHINESE JOURNAL OF ANALYTICAL CHEMISTRY

ISSN： 0253-3820

年卷期： 2011 年 39 卷 5 期

页码：

收录情况： SCI

摘要： A sensitive liquid chromatography tandem mass spectrometric (LC-MS/MS) method has been developed for simultaneous determination of bacitracin, colistin A, colistin B, virginiamycin and vancomycin in bovine milk samples. Milk samples were extracted with a mixture of methanol 0. 1% formic acid and water, and deproteinized with 4% trichloroacetic acid in acetonitrile. The five peptide antibiotics in the extract were separated on a reversed phase using a gradient elution program of 0.1% formic acid aqueous solution (A) and 0.1% formic acid in acetonitrile solution (B). Using LC-MS/MS (EST) with multiple reaction monitoring (MRM), identification of the major components of the five kinds of peptide antibiotics was performed based upon the intensities of mass fragments from the respective doubly or triply charged precursor ions. The recoveries were 75. 1%-120. 1% for the five polypeptides at spiked levels of 25, 50 and 100 mu g/kg, and the relative standard deviation (RSD) was less than 15.7%. The limit of detection (LOD) for the five peptide antibiotics was 0. 2-5. 6 mu g/kg. The method is suitable for quantitative and qualitative analysis of peptide antibiotics in a sufficient number of samples with simplicity, sensitivity and repeatability, and which could meet the request of peptide antibiotic residue testing at home and abroad.

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