数字农科院2.0

Isolation and identification of 5-hydroxyl-5-methyl-2-hexenoic acid from Actinoplanes sp HBDN08 with antifungal activity

文献类型： 外文期刊

作者： Zhang, Ji;Wang, Xiang-Jing;Yan, Yi-Jun;Jiang, Ling;Wang, Ji-Dong;Xiang, Wen-Sheng;Li, Bao-Ju

作者机构：

关键词： Actinoplanes sp HBDN08;Antifungal activity;5-Hydroxyl-5-methy1-2-hexenoic acid

期刊名称： BIORESOURCE TECHNOLOGY

ISSN： 0960-8524

年卷期： 2010 年 101 卷 21 期

页码：

收录情况： SCI

摘要： A bioactivity-guided approach was employed to isolate and determine the chemical identity of bioactive constituents with antifungal activity from Actinoplanes sp. HBDN08. The structure of the antifungal metabolite was elucidated as 5-hydroxyl-5-methyl-2-hexenoic acid on the basis of spectral analysis. This compound showed strong in vitro antifungal activity against Botrytis cinerea, Cladosporium cucumerinum and Corynespora cassiicola, with an IC(50) of 32.45, 27.17, and 30.66 mg/L, respectively; however, it only moderately inhibited hyphal growth of Rhizoctonia solani with an IC(50) of 61.64 mg/L. The in vivo antifungal activity under greenhouse conditions demonstrated that 5-hydroxyl-5-methyl-2-hexenoic acid could effectively control the diseases caused by B. cinerea, C. cucumerinum and C. cassiicola with 71.42%, 78.63% and 65.13% control values at 350 mg/L, respectively. This strong antifungal activity suggests that 5-hydroxyl-5-methyl-2-hexenoic acid might be a promising candidate for new antifungal agents. (C) 2010 Elsevier Ltd. All rights reserved.

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