数字农科院2.0

Junctional Diversity in Xenopus tropicalis Immunoglobulin Light Chains

文献类型： 外文期刊

作者： Qin Tong;Ren Li-Ming;Meng Qing-Yong

作者机构：

关键词： Xenopus tropicalis;immunoglobulin;light chain;recombination;diversity

期刊名称： PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

ISSN： 1000-3282

年卷期： 2010 年 37 卷 11 期

页码：

收录情况： SCI

摘要： Xenopus tropicalis is an important model animal in immunology Based on the available genome data, the genomic organization of all three light chain gene (p, sigma and type III) loci were recently characterized in Xenopus tropical is On the basis of similarity of protein sequences, genomic organization and chromosomal location of the light chain genes among frogs and mammals, the data strongly support the previous suggestions that the p genes belong to the kappa gene lineage, whereas the type III genes share a common origin with the lambda genes About 200 cDNA fragments from each of p, sigma and type ill genes, were cloned and sequenced respectively generating 22, 25 and 44 clones that have unique VJ junctions (after removal of redundant clones) Recombined VJ junctions of cloned light chain cDNA were analyzed, which showed a paucity of N and P nucleotides in expressed p, if and type III genes They also show that somatic VJ rearrangements of the sigma gene seemed to be dependent on short stretches of homologous nucleotides (microhomology) The microhomology-directed VJ recombination obviously results in very limited diversity However, most expressed p and type III VJ junctions showed direct ligation or deletions of V and J coding ends These results help researchers to understand the generation of Ig diversity in X tropicalis

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