数字农科院2.0

Toll-Like Receptor 2 Gene Polymorphism and its Relationship with SCS in Dairy Cattle

文献类型： 外文期刊

作者： Zhang, L. P.;Li, H. D.;Li, J. Y.;Gao, X.;Chen, J. B.;Ren, H. Y.;Xu, S. Z.;Gan, Q. F.;Wang, X. P.;Xu, S. Z.;Ma, T. H.

作者机构：

关键词： Dairy cattle;Mastitis;TLR2

期刊名称： ANIMAL BIOTECHNOLOGY

ISSN： 1049-5398

年卷期： 2009 年 20 卷 3 期

页码：

收录情况： SCI

摘要： Toll-like receptor 2 (TLR2) plays an important role in the innate immune response to a variety of pathogens. In this study, bovine TLR2 gene was taken as a candidate gene for mastitis resistance. Through PCR-SSCP analysis and sequencing, three missense mutations at T385G, G398A, and G1884A were detected in the coding region that encoded extracellular domain. Altogether 240 dairy cattle of three breeds (Holstein, Simmental, and Sanhe cattle) were genotyped and allele frequencies were determined. The effects of TLR2 polymorphisms on somatic cell score (SCS) were analyzed and significant association was found between T385G and SCS. The mean of genotype GG was significantly lower than those of genotype TT and TG. No significant associations were found with SCS for G398A and G1884A. Information provided in this research will be useful in further studies to determine the role of TLR2 gene in the mastitis resistance.

分类号：

  • 相关文献

[1]牛分枝杆菌重组蛋白TB10.4对RAW264.7细胞TLR2表达和分布的影响. 刘淑清,李平俊,鑫婷,侯绍华,朱鸿飞,贾红. 2015

[2]TLR2介导鸡毒支原体脂质相关膜蛋白诱导DF-1细胞表达IL-1β的研究. 陈莹,汪洋,于颖,李媛,王琪,邵家日,王显兵,周长平,李继昌,辛九庆. 2017

[3]五指山小型猪近交系主动脉内皮细胞体外培养模型的建立和TLR2介导炎症相关因子的表达. 王攀,陶晓莉,沈祖楠,李和刚,潘杰,牟玉莲,李奎. 2012

[4]Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. Liu, Shuqing,Jia, Hong,Hou, Shaohua,Zhang, Gaimei,Xin, Ting,Yuan, Weifeng,Guo, Xiaoyu,Li, Ming,Wu, Jing,Zhu, Hongfei,Li, Hegang,Li, Hegang,Gao, Xintao. 2014

[5]High mobility group box-1 regulates expression of EGFR, VEGF, StAR and TIMP1/2 in bovine granulosa cells through a mechanism involving TLR2/NF-κB. Yingying Xie,Kang Zhang,Jingyan Zhang,Kai Zhang,Xuequan Hu,Lei Wang,Xuezhi Wang,Jianxi Li. 2022

[6]Cysticercus pisiformis-derived novel-miR1 targets TLR2 to inhibit the immune response in rabbits. Guoliang Chen,Guiting Pu,Liqun Wang,Yanping Li,Tingli Liu,Hong Li,Shaohua Zhang,Xuelin Wang,Xiaolei Liu,Xuenong Luo. 2023

[7]Curcumin Alleviates HMGB1-Mediated Inflammation Through the Signaling Pathway of TLR2-NF-κB in Bovine Ovarian Granulosa Cells. Siqi Liu,Yingying Xie,Lei Wang,Jingyan Zhang,Xiaoliang Chen,Xiaowei Feng,Junyan Wang,Kang Zhang,Jianxi Li. 2025

[8]Recombinase polymerase amplification (RPA) combined with lateral flow (LF) strip for equipment-free detection of Cryptosporidium spp. oocysts in dairy cattle feces. Wu, Yao-Dong,Zhou, Dong-Hui,Zheng, Wen-Bin,Ma, Jian-Gang,Wang, Meng,Zhu, Xing-Quan,Xu, Min-Jun,Zhang, Long-Xian,Zheng, Wen-Bin,Ma, Jian-Gang,Xu, Min-Jun.

[9]Embedded system design of linear type score for Holstein cattle on PDA. Pang, Zhihong,Xiong, Benhai,Luo, Qingyao,Lu, Jianqiang. 2007

[10]Prevalence and molecular characterization of Cryptosporidium spp. in dairy cattle, northwest China. Zhang, Xiao-Xuan,Tan, Qi-Dong,Zhou, Dong-Hui,Ni, Xiao-Ting,Liu, Guang-Xue,Yang, Yan-Chuan,Zhu, Xing-Quan,Zhang, Xiao-Xuan,Tan, Qi-Dong.

[11]Seroprevalence and correlates of Toxoplasma gondii infection in dairy cattle in northwest China. Tan, Qi-Dong,Yang, Xiao-Yu,Yin, Ming-Yang,Hu, Ling-Ying,Qin, Si-Yuan,Wang, Jin-Lei,Zhou, Dong-Hui,Zhu, Xing-Quan,Tan, Qi-Dong,Zhou, Dong-Hui,Zhu, Xing-Quan,Yin, Ming-Yang,Hu, Ling-Ying,Qin, Si-Yuan,Zhu, Xing-Quan.

[12]A SNP in the 3 '-UTR of HSF1 in dairy cattle affects binding of target bta-miR-484. Li, Q. L.,Xia, P.,Wang, Y. J.,Wu, Z. Y.,Jia, Y. H.,Chang, S. M.,Zhang, Z. F.,Li, Q. L.,Chu, M. X.. 2015

[13]AMMONIA AND GREENHOUSE GAS EMISSIONS FROM A DAIRY CATTLE BARN WITH A DAILY MANURE COLLECTION SYSTEM. Dong, H.. 2012

[14]Seroprevalence of chlamydial infection in dairy cattle in Guangzhou, southern China. Zhou, Dong-Hui,Zhao, Fu-Rong,Xia, Hui-Yan,Xu, Min-Jun,Huang, Si-Yang,Song, Hui-Qun,Zhu, Xing-Quan,Zhu, Xing-Quan. 2013

[15]Seroprevalence of Toxoplasma gondii infection in dairy cattle, in Jinzhou, Northeastern China. Bao, M.,Wang, S. D.,Tang, F.,Qu, L. D.,Tian, Y. M.,Zhou, D. H.,Xu, M. J.,Wu, S. M.,Song, H. Q.,Tian, Y. M.,Wu, S. M.. 2012

[16]First report of Mycoplasma bovis infection in dairy cattle in Guangzhou, subtropical southern China. Zhao, Fu-Rong,Zhu, Xue-Liang,Xu, Min-Jun,Huang, Si-Yang,Zhou, Dong-Hui,Xia, Hui-Yan,Song, Hui-Qun,Xia, Hui-Yan,Song, Hui-Qun,Zou, Feng-Cai. 2012

[17]Prevalence Of Cryptosporidium In Dairy C.attle In China During 2 008-2018: A Systematic Review And Meta-Analysis. Cai, YN,Zhang, NZ,Gong, QL,Zhao, Q,Zhang, XX. 2019

[18]Identification and isolation of pathogenic Theileria orientalis Ikeda genotype from confined dairy cattle, in Hebei, China. Liu, Junlong,Li, Zhi,Liu, Aihong,Wang, Jinming,Guan, Guiquan,Yin, Hong,Luo, Jianxun. 2022

[19]Determination of genetic effects and functional SNPs of bovine HTR1B gene on milk fatty acid traits. Mingyue Cao,Lijun Shi,Peng Peng,Bo Han,Lin Liu,Xiaoqing Lv,Zhu Ma,Shengli Zhang,Dongxiao Sun. 2021

[20]Prevalence and novel genotypes identification of enterocytozoon bieneusi in dairy cattle in Yunnan Province, China. Hai Yang Song,Kai Sheng Wang,Jian Fa Yang,Hua Ming Mao,Li Hua Pu,Yang Zou,Jun Ma,Xing Quan Zhu,Feng Cai Zou,Jun Jun He. 2021

作者其他论文 更多>>