数字农科院2.0

Elucidating enantioselective toxicity mechanism of chiral fungicide tebuconazole to Eisenia fetida: Phenotypic analysis and multi-omics integration

文献类型： 外文期刊

作者： Ziyang Diao;Jiqiang Fu;Jingyang Zhao;Jishi Wang;Wenjing Liu;Yanwei Zhang;Zeying He

作者机构：

关键词： Earthworms;Enantioselective bioaccumulation;Multi-omics;Tebuconazole;Toxicity mechanism

期刊名称： Journal of Hazardous Materials

ISSN： 0304-3894

年卷期： 2025 年 498 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： The widespread application of chiral fungicide tebuconazole (TEB) has led to its frequent detection in the environment. However, limited information is available regarding its potential toxicological effects on non-target soil organisms, particularly concerning enantioselective metabolic perturbations. In this study, the enantioselective toxicity of TEB on earthworms (Eisenia fetida) was investigated over a 20-day exposure at 5 mg/kg using a multi-omics approach that integrated transcriptome, metabolome, and microbiota analysis. Phenotypic analysis revealed that R-(-)-TEB accumulated preferentially than S-(+)-TEB (p < 0.05), and was distributed widely across the digestive tract and hindgut, whereas S-(+)-TEB was concentrated in the anterior digestive system. S-(+)-TEB induced more severe oxidative stress, as higher MDA level, disrupted antioxidant enzyme activities, and muscle damage. Transcriptomic and metabolomic integrative analysis revealed R-(-)-TEB primarily disrupted nucleotide metabolism, leading to impaired nucleic acid synthesis and energy supply, while S-(+)-TEB uniquely perturbed carbohydrate metabolism and downregulated CYP450-mediated external pollutant metabolism, leading to energy metabolic imbalance and the reduced capacity for pollutant biotransformation. Gut microbiota exhibited enantioselective responses to enhanced stress protection. Collectively, these findings provide insights into the toxicological mechanisms of TEB on earthworms at the enantiomeric level, and underscore the metabolic health risks posed by chiral fungicide exposure in soil environments.

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