数字农科院2.0

The Plasma Load of Inoculated EIAV Vaccine Strain EIAV(FDDV) Was Not Boosted by Immune Suppression

文献类型： 外文期刊

作者： Ma Jian;Jiang Cheng-Gang;Lin Yue-Zhi;Guo Liang;Guo Wei;Kong Xian-Gang;Shen Rong-Xian;Zhou Jian-Hua;Ma Jian;Guo Liang;Shao Yi-Ming;Zhang Xiao-Yan

作者机构：

关键词： EIAV(FDDV);attenuated vaccine;immune suppress;lymphocyte proliferation;plasma viral load

期刊名称： PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

ISSN： 1000-3282

年卷期： 2008 年 35 卷 11 期

页码：

收录情况： SCI

摘要： The attenuated Chinese equine infectious anemia virus (EIAV) vaccine is the first lentiviral vaccine that provides solid protective immunities to vaccinated horses. To investigate properties of EIAV vaccine, especially the relationship between its replication and the immunity, viral plasma loads of an EIAV vaccine strain EIAV(FDDV) in immune suppressed horses were detected. Three horses, which were immunized with EIAV(FDDV) for 16 months, were treated with dexamethasone for 14 days to suppress their immunities. Reduced immune response in these animals was confirmed by significantly declined lymphocyte proliferation rate detected after 10 days of the drug treatment. The plasma viral loads of EIAV(FDDV), which was indicated by the genomic RNA copy numbers, in horses before and after the treatment of dexamethasone were monitored by real time RT-PCR. Results revealed that the viral plasma loads in two of three immune-suppressed horses were kept a steady low level around 10(3)similar to 10(4) copies/ml. The load was increased by 10 folds in the third horse, but was still among the standard levels for EIAV(FDDV) vaccinated horses. As a positive control, the viral copy number of an asymptomatic carrier of EIAV virulent strain EIAV(Liao) was jumped nearly 25 000-fold higher after being treated with dexamethasone. The typical clinical symptoms of EIA, characterized by febrile episodes and thrombocytopenia, were also appeared in this horse. These results clearly indicate that it is the unique biological feature of the attenuated EIAV vaccine, but not the immunity, resulted in EIAV(FDDV) remaining in low levels in the body harmlessly. In addition, the steady low level of viremia and the inability to cause clinical symptoms. of EIAV(FAAD) in immune-suppressed hosts further demonstrated the safety of attenuated Chinese EIAV vaccines. The data provide a new sight for studies on the immunity to lentiviruses.

分类号：

  • 相关文献

[1]Effect of supplemental beta-carotene in the periparturient diet on plasma vitamin A and beta-carotene concentrations and lymphocyte proliferation in Holstein cows. He, W. J.,Ren, L. P.,Meng, Q. X.,He, W. J.,Ren, L. P.,Meng, Q. X.,Zhang, Q. D.. 2007

[2]Cordyceps militaris polysaccharides can improve the immune efficacy of Newcastle disease vaccine in chicken. Wang, Mi,Qin, Tao,Hu, Yuanliang,Wang, Mi,Meng, Xinyu,Yang, Ruile,Li, Ying,Zhang, Lifang,Fei, Chengzhong,Zhen, Wenli,Zhang, Keyu,Wang, Xiaoyang,Xue, Feiqun.

[3]Sulfated glucan can improve the immune efficacy of Newcastle disease vaccine in chicken. Wang, Mi,Yang, Ruile,Zhang, Lifang,Meng, Xinyu,Fei, Chenzhong,Zhang, Keyu,Wang, Xiaoyang,Zheng, Wenli,Xiao, Sui,Zhang, Saiqi,Xue, Feiqun,Wang, Mi,Hu, Yuanliang.

[4]Immunomodulatory activities of a new pentapeptide (Bursopentin) from the chicken bursa of Fabricius. Li, D. Y.,Chen, P. Y.,Geng, Z. R.,Zhu, H. F.,Miao, D. N.,Wang, C..

[5]Microbial ecology of swine farms and PRRS vaccine vaccination strategies. Zhao, Zhanzhong,Lai, Zhi,Guo, Xin,Yang, Hanchun,Zhao, Zhanzhong,Lai, Zhi,Guo, Xin,Yang, Hanchun,Zhao, Zhanzhong,Qin, Yuming,Wang, Liyong,Peng, Liying,Cai, Xuehui. 2012

[6]Establishment of reverse transcription loop-mediated isothermal amplification for rapid detection and differentiation of canine distemper virus infected and vaccinated animals. Liu, Da-Fei,Chai, Hong-Liang,Yin, Xiu-Chen,Hua, Yu-Ping,Liu, Da-Fei,Liu, Chun-Guo,Tian, Jin,Zhang, Xiao-Zhan,Yang, Tian-Kuo,Zhang, Hong-Ying,Liu, Ming,Qu, Lian-Dong,Jiang, Yi-Tong.

[7]Amino acid mutations of the infectious clone from Chinese EIAV attenuated vaccine resulted in reversion of virulence. Shen, T,Liang, H,Tong, X,Fan, XJ,He, X,Ma, Y,Xiang, WH,Shen, RX,Zhang, XY,Shao, YM. 2006

[8]Live Attenuated Pru:Delta Cdpk2 Strain O.f Toxoplasma Gondii Protects A gainst Acute, Chronic, And Congenital Toxoplasmosis. Wang, JL,Li, TT,Elsheikha, HM,Chen, K,Cong, W,Yang, WB,Bai, MJ,Huang, SY,Zhu, XQ. 2018

[9]Assessing the Risk of Commercial Vaccines Against Pseudorabies Virus in Cats. Tu, Lu,Zhao, Jingjie,Chen, Qiuyang,Zhang, Shan,Liang, Lin,Tang, Xinming,Hou, Shaohua,Yang, Weifang,Liang, Ruiying. 2022

[10]A New Strategy of Cross-Protection Based on Attenuated Vaccines: RNA Viruses Are Used as Vectors to Control DNA Viruses. Mingjing Zhu,Shanshan Liu,Zhao Wang,Chengming Yu,Xuefeng Yuan. 2023

[11]Protective efficacy of a candidate live attenuated vaccine derived from the SD-R strain of lineage 1 porcine reproductive and respiratory syndrome virus against a lethal challenge with HP-PRRSV HuN4 in piglets. Zhang, Hongliang,Li, Chao,Xu, Hu,Gong, Bangjun,Li, Wansheng,Guo, Zhenyang,Xiang, Lirun,Sun, Qi,Zhao, Jing,Peng, Jinmei,Wang, Qian,Zhou, Guohui,Tang, Yan-Dong,An, Tongqing,Cai, Xue-Hui,Tian, Zhi-Jun. 2023

作者其他论文 更多>>