数字农科院2.0

A Structure Identification and Toxicity Assessment of the Degradation Products of Aflatoxin B-1 in Peanut Oil under UV Irradiation

文献类型： 外文期刊

作者： Mao, Jin;He, Bing;Zhang, Liangxiao;Li, Peiwu;Zhang, Qi;Ding, Xiaoxia;Zhang, Wen;Mao, Jin;He, Bing;Zhang, Liangxiao;Li, Peiwu;Zhang, Qi;Zhang, Wen;Mao, Jin;Li, Peiwu;Zhang, Qi;Ding, Xiaoxia;Zhang, Liangxiao;Li, Peiwu;Zhang, Qi;Ding, Xiaoxia;Zhang, Wen

作者机构：

关键词： aflatoxin B-1;photodegradation product;TQEF-MS/MS;cell viability;furan rings

期刊名称： TOXINS

ISSN： 2072-6651

年卷期： 2016 年 8 卷 11 期

页码：

收录情况： SCI

摘要： Aflatoxins, a group of extremely hazardous compounds because of their genotoxicity and carcinogenicity to human and animals, are commonly found in many tropical and subtropical regions. Ultraviolet (UV) irradiation is proven to be an effective method to reduce or detoxify aflatoxins. However, the degradation products of aflatoxins under UV irradiation and their safety or toxicity have not been clear in practical production such as edible oil industry. In this study, the degradation products of aflatoxin B-1 (AFB(1)) in peanut oil were analyzed by Ultra Performance Liquid Chromatograph-Thermo Quadrupole Exactive Focus mass spectrometry/mass spectrometry (UPLC-TQEF-MS/MS). The high-resolution mass spectra reflected that two main products were formed after the modification of a double bond in the terminal furan ring and the fracture of the lactone ring, while the small molecules especially nitrogen-containing compound may have participated in the photochemical reaction. According to the above results, the possible photodegradation pathway of AFB(1) in peanut oil is proposed. Moreover, the human embryo hepatocytes viability assay indicated that the cell toxicity of degradation products after UV irradiation was much lower than that of AFB(1), which could be attributed to the breakage of toxicological sites. These findings can provide new information for metabolic pathways and the hazard assessment of AFB(1) using UV detoxification.

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