数字农科院2.0

Gentamicin removal in submerged fermentation using the novel fungal strain Aspergillus terreus FZC3

文献类型： 外文期刊

作者： Liu, Yuanwang;Li, Zhaojun;Zhang, Cheng;Feng, Yao;Cheng, Dengmiao;Chang, Huiqing

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期刊名称： SCIENTIFIC REPORTS

ISSN： 2045-2322

年卷期： 2016 年 6 卷

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收录情况： SCI

摘要： Social concern and awareness of the potential risk posed by environmental residues of antibiotics such as gentamicin in the development of antibiotic resistance genes have increased. The present study used laboratory-scale experiments to develop methods for gentamicin removal from the environment. A fungus, strain FZC3, which could remove gentamicin in submerged fermentation, was isolated from solid waste and sewage water from a gentamicin production factory. The fungus was identified as Aspergillus terreus by sequencing the PCR-amplified ITS fragments of its rRNA-coding genes and by its morphology. The gentamicin removal efficiency exceeded 95% by day 7 under optimized culture conditions. The results showed that both biosorption and biodegradation were involved. We speculated that Aspergillus terreus FZC3 absorbed gentamicin and subsequently degraded it. We also found that Aspergillus terreus FZC3 survived and maintained a high bioremediation efficiency over a wide pH range, indicating its potential for future use in the large-scale bioremediation of gentamicin.

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