数字农科院2.0

HIV-1 and BLV are insensitive to SERINC5 restriction under the cell-cell infection

文献类型： 外文期刊

作者： Yu, Changqing;Jiang, Faming;Li, Yujing;Li, Qiushui;Tokunaga, Kenzo;Yang, Dan;Xu, Chao;Li, Nan;Li, Sunan;Khan, Ilyas;Xian, Yuanhua;Xia, Changyou;Zhang, He

作者机构：

关键词： serine incorporator 5;retrovirus;HIV-1;BLV;cell-cell;restriction

期刊名称： MICROBIOLOGY SPECTRUM

ISSN：

年卷期： 2025 年

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收录情况： SCIE（2025版）

摘要： Serine incorporator 5 (SERINC5, SER5) suppresses viral cell-free infection. However, its antiviral potency under viral cell-cell infection is not examined yet. Here, we established the in vitro cell-cell infection systems to assess SER5's antiviral activity on HIV-1 and bovine leukemia virus (BLV). Our results showed SER5 from different mamma lian species, including Homo sapiens, Bos taurus, and Felis catus, was capable of signifi cantly inhibiting HIV-1 cell-free infection. However, these SER5s were unable to restrict HIV-1 cell-cell infection. Intriguingly, Ebola virus glycoprotein-mediated pseudoviral cell-free infection was greatly enhanced by Homo sapiens and Bos taurus SER5. Notably, BLV was also insensitive to SER5-mediated restriction under the cell-cell infection. In addition, BLV envelope glycoproteins, which contained one glycosylation variation, were not restricted by SER5 in the model of cell-cell infection. Overall, our results indicated SER5 was ineffective against HIV-1 and BLV under the cell-cell infection, which was utilized by them to circumvent SER5-imposed restriction in vitro and may aid their transmission in vivo.

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