数字农科院2.0

Whole-grain black rice diet rewires the single-cell transcriptomic landscape of age-related ovarian decline in mice

文献类型： 外文期刊

作者： Tu, Yi-Xuan;Wang, Dan-Yang;Ma, Jun;Yu, Ke-Chun;Li, Sheng-Hui;Li, Bo-Han;Deng, Xin-Yin;Li, Shan;Wang, Hong-Kai;Yin, Tailang;Wang, Ling;Chen, Zhen-Xia

作者机构：

关键词： ovary aging;whole-grain black rice;single-cell RNA sequencing;granulosa cells;female reproductive health

期刊名称： SCIENCE CHINA-LIFE SCIENCES

ISSN： 1674-7305

年卷期： 2026 年

页码：

收录情况： SCIE（2025版） ; ; CSCD（2025-2026年度） ; ; 科技核心（2024版）

摘要： Ovarian aging poses significant challenges to female fertility and overall health. While whole-grain black rice diet (BRD) has emerged as a promising anti-aging intervention, its translational potential for ovarian health remains underexplored. This study systematically evaluated BRD's effects on ovarian functional decline through single-cell profiling and phenotypic validation. We demonstrated that BRD intervention effectively delays ovarian aging by preserving the ovarian reserve and maintaining hormonal balance, with granulosa cells (GCs) exhibiting the most pronounced responsiveness. Notably, BRD counteracts age-associated reductions in the GCs population and restores ovarian functional capacity. These findings highlight BRD's ability to rejuvenate the ovarian cellular landscape and stabilize aging-related tran-scriptional profiles. Our study provides actionable insights for developing BRD-based nutritional strategies to combat female reproductive aging, paving the way for clinically translatable dietary interventions and functional food innovations targeting the extension of women's healthspan.

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