数字农科院2.0

Nobiletin and Tangeretin facilitate interfacial migration and inhibit lipid digestion through their binding interactions with bile salts

文献类型： 外文期刊

作者： Xin Huang;Wenhui Li;Fei Pan;Qinfei Ke;Xingran Kou

作者机构：

关键词： Bile salts;Lipid digestion inhibition;Nobiletin;Oil-water interface;Tangeretin

期刊名称： Food Chemistry

ISSN： 0308-8146

年卷期： 2025 年 495 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： The interfacial migration of bioactive molecules modulates the properties of the oil-water interface, effectively retarding lipid digestion. The polymethoxyflavones, such as Nobiletin (NBT) and Tangeretin (TAN), abundant in Citri reticulatae pericarpium, exhibit interfacial activity and inhibit lipolysis. This study used fourier transform infrared spectroscopy, molecular dynamics simulation, rheological analysis, and FFA release kinetics measurement to elucidate its mechanism of action. The results indicate that interfacial migration shows markedly superior inhibitory efficacy to lipase inhibition for interfacially active flavour molecules (p < 0.05). Ultraviolet-visible analysis revealed that bile salts (BS) significantly enhanced spice molecule migration (NBT: 6.80-fold, TAN: 12.31-fold), potentially disrupting BS interface stability through binding and interfacial migration. These findings show how spice molecules migrating to the interface inhibit lipid digestion, highlighting their potential as natural agents for weight management. The research results provide a theoretical basis for the development of healthy food.

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