文献类型： 外文期刊
作者： Yuan Ji 1; Yan Sun 1; Hejie Zhou 1; Zimeng Liu 2; Ziran Sun 1; Gencheng Xu 1; Hongzhi Wen 1; Zerong Zheng 1; Lixiang Tu 1; Zitong Yang 1; Yuanyan Zhang 1; Xi Liu 1; Shirong Zhou 1; Xiaoou Dong 1; Yanpeng Wang 2; Chao Li 1 3; Jianmin Wan
关键词： OMEGA−Fanzor
期刊名称： Journal of Integrative Plant Biology
ISSN： 1672-9072
年卷期： 2025 年
页码：
收录情况： SCIE（2025版） ; ; CSCD（2025-2026年度） ; ; 科技核心（2024版）
摘要： The genome editing tools based on Cas9 and Cas12 are widely used inplants, and evolved from IS200/605 transposon‐like proteins IscB andTnpB, respectively (Altae‐Tran et al., 2021). Prokaryotic TnpB, guided byωRNA, cleaves target DNA adjacent to a target adjacent motif (TAM) andcan mediate genome editing activity in eukaryotic cells (Karmakar et al.,2024). Fanzor (Fz), characterized as an eukaryotic homolog of TnpB, alsobelongs to the obligate mobile element guided activity (OMEGA) system(Saito et al., 2023). Compared with Cas12, Fanzor has similar charac-teristics with a half size, ~620 amino acids (aa) (Jiang et al., 2023).However, the editing activity of OMEGA−Fanzor systems in plants re-mains limited
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