数字农科院2.0

Gut microbiome in tumorigenesis and therapy of colorectal cancer

文献类型： 外文期刊

作者： Ling Wang;; Ke‐Chun Yu;;Yun‐qing Hou;;Min Guo;; Fan Yao;; Zhen‐Xia Chen

关键词： biomarkers; CRC; gut microbiome; probiotics; tumorigenesis

期刊名称： JOURNAL OF CELLULAR PHYSIOLOGY

ISSN： 0021-9541

年卷期： 2023 年

页码：

收录情况： SCIE（2023版）

摘要： Colorectal cancer (CRC) is the malignant tumor with the highest incidence in the digestive system, and the gut microbiome plays a crucial role in CRC tumorigenesis and therapy. The gastrointestinal tract is the organ harboring most of the microbiota in humans. Changes in the gut microbiome in CRC patients suggest possible host–microbe interactions, thereby hinting the potential tumorigenesis, which provides new perspective for preventing, diagnosing, or treating CRC. In this review, we discuss the effects of gut microbiome dysbiosis on CRC, and reveal the mechanisms by which gut microbiome dysbiosis leads to CRC. Gut microbiome modulation with the aim to reverse the established gut microbial dysbiosis is a novel strategy for the prevention and treatment of CRC. In addition, this review summarizes that probiotic antagonize CRC tumorigenesis by protecting intestinal barrier function, inhibiting cancer cell proliferation, resisting oxidative stress, and enhancing host immunity. Finally, we highlight clinical applications of the gut microbiome, such as gut microbiome analysis‐based biomarker screening and prediction, and microbe modulation‐based CRC prevention, treatment enhancement, and treatment side effect reduction. This review provides the reference for the clinical application of gut microbiome in the prevention and treatment of CRC.

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