数字农科院2.0

Effects of a Novel Bovine Lactoferrin-Derived Peptide on the Intestinal Morphology and Intestinal Flora in Rats

文献类型： 外文期刊

作者： Huang, Tianle;Yang, Huan;Zhao, Yang;Cui, Haiyue;Qi, Xiaoxi;Miao, Liguang

作者机构：

关键词： bovine lactoferrin;intestinal morphology;intestinal flora

期刊名称： MICROORGANISMS

ISSN：

年卷期： 2025 年 13 卷 5 期

页码：

收录情况： SCIE（2025版）

摘要： Bovine lactoferrin-derived peptide LF-MQL was administered to healthy rats to assess its effects on growth parameters and gut morphology. Faecal samples were analysed by 16S rRNA high-throughput sequencing to investigate the modulatory effects of LF-MQL on the composition and diversity of the gut microbiota. The results showed that both experimental groups maintained intact intestinal organization. Notably, supplementation with LF-MQL significantly increased the length of small intestinal villi compared to the control group (p < 0.05), and an improvement in the structural organization of the villi, including a more ordered and compact arrangement, was observed. These morphological findings suggest that there are no adverse effects associated with LF-MQL administration. In addition, administration of LF-MQL modulates the functional activity of the gut microbiota and regulates their involvement in host-related metabolic pathways, thereby improving gut homeostasis. These findings provide a theoretical basis for evaluating the safety of bovine lactoferrin peptides in food and pharmaceutical applications.

分类号：

  • 相关文献

[1]Effects of dietary supplementation of bovine lactoferrin on growth performance, immune function and intestinal health in weaning piglets. Ma, Xuanxuan,Hao, Ya,Mao, Ruoyu,Yang, Na,Zheng, Xueling,Li, Bing,Wang, Zhenlong,Zhang, Qingjuan,Teng, Da,Wang, Jianhua. 2022

[2]Treatment of lactoferrin and antimicrobial peptide N6 on bacterial enteritis caused by Escherichia coli in mice. Ma, Xuanxuan,Zhang, Kun,Yang, Na,Hao, Ya,Mao, Ruoyu,Teng, Da,Wang, Jianhua. 2024

[3]Contribution of bovine lactoferrin inter-lobe region to iron binding stability and antimicrobial activity against Staphylococcus aureus. Bai, Xuejing,Teng, Da,Tian, Zigang,Zhu, Yanping,Yang, Yalin,Wang, Jianhua,Bai, Xuejing,Teng, Da,Tian, Zigang,Zhu, Yanping,Yang, Yalin,Wang, Jianhua.

[4]Understanding the pH-dependent interaction of anthocyanin with two food-derived transferrins. Wenxin Wang,Peiqing Yang,Zhenzhen Xu,Liang Zhao,Yongtao Wang,Xiaojun Liao. 2023

[5]Study of SI-traceable purity assessment of bovine lactoferrin using mass balance approach and amino acid-based isotope dilution liquid chromatography-mass spectrometry. Jingjing Yan,Min Wang,Mengrui Yang,Jian Zhou,Xiaofeng Xue,Tongtong Wang. 2022

[6]Development and validation of signature peptide-based isotope dilution liquid chromatography-mass spectrometry for bovine lactoferrin purity assessment. Yan, Jingjing,Yang, Mengrui,Wang, Min,Han, Yiyi,Zhou, Jian,Ma, Yingqing,Wang, Tongtong,Li, Liang. 2025

[7]In vitro efficacy of bovine lactoferrin against bovine viral diarrhea virus. Hongwei Cui,Songda Li,Xiaohuan Yan,Zhaohua Wang,Tianyi Leng,Ming Li,Songli Li. 2025

[8]Sorghum resistant starch reduces adiposity in high-fat diet-induced overweight and obese rats via mechanisms involving adipokines and intestinal flora. Shen, Rui-Ling,Zhang, Wen-Li,Dong, Ji-Lin,Chen, Ming,Ren, Gui-Xing.

[9]Effects of chlorogenic acid on growth, metabolism, antioxidation, immunity, and intestinal flora of crucian carp (Carassius auratus). Jin, Xuexia,Su, Mengyuan,Liang, Yunxiang,Li, Yingjun. 2023

[10]Host Metabolic Disorders Induced by Alterations in Intestinal Flora under Dietary Pesticide Exposure. Jingkun Liu,Fangfang Zhao,Tianrun Wang,Yanyang Xu,Jing Qiu,Yongzhong Qian. 2021

[11]Probiotics Isolated From Animals in Northwest China Improve the Intestinal Performance of Mice. Yingying Li,Dan Jia,Jiahui Wang,Hehai Li,Xijuan Yin,Junlong Liu,Jinming Wang,Guiquan Guan,Jianxun Luo,Hong Yin,Sa Xiao,Youquan Li. 2021

[12]Effects of sulfated β-glucan from Saccharomyces cerevisiae on growth performance, antioxidant ability, nonspecific immunity, and intestinal flora of the red swamp crayfish (Procambarus clarkii). Huang Q.,Zhu Y.,Yu J.,Fang L.,Li Y.,Wang M.,Liu J.,Yan P.,Xia J.,Liu G.,Yang X.,Zeng J.,Guo L.,Ruan G.. 2022

[13]Fabrication of Human Milk Fat Substitute: Based on the Similarity Evaluation Model and Computer Software. Huiquan Zhu,Pu Zhao,Xiaodan Wang,Yunna Wang,Shuwen Zhang,Xiaoyang Pang,Jiaping Lv. 2024

[14]Changes in PI3K/AKT and NRF2/HO-1 signaling expression and intestinal microbiota in bleomycin-induced pulmonary fibrosis. Chenchen Li,Yuxia Cao,Yousheng Peng,Ting Ma,Fanlin Wu,Yongli Hua,Xiuqin Wang,Tong Bai,Yanming Wei,Peng Ji. 2024

[15]Immunomodulatory Effects of Sodium Hyaluronate Health Drink on Immunosuppressed Mice. Xiaozhen Peng,Xiaoqiao Yao,Ya Liu,Bangzhu Peng. 2024

[16]Selenomethionine Mitigates Oxidized Soybean Oil-Induced Jejunal Injury via Antioxidant, Metabolic Reprogramming, and Immunomodulatory Pathways. Huihui Tian,Luxi Lin,Pingyang Li,Yiyu Yin,Kehan Ma,Qingyu Zhao,Junmin Zhang,Chaohua Tang. 2025

[17]Effects of substituting fishmeal with barley worms (Zophobas morio) in diets on growth performance, serum parameters, Immunocompetence, and intestinal health of juvenile leopard coral grouper (Plectropomus leopardus). Xin Zhang,Tingting Wang,Min Xue,Xiaofang Liang,Adinda Luthfiah,Kangze Xv,Dengbao Fan,Beiping Tan,Wei Zhang. 2026

[18]Effects of dietary gallic acid supplementation on performance, antioxidant status, and jejunum intestinal morphology in broiler chicks. Samuel, K. G.,Wang, J.,Yue, H. Y.,Wu, S. G.,Zhang, H. J.,Qi, G. H.,Duan, Z. Y..

[19]Effects of coated sodium butyrate on growth performance, intestinal morphology, and caecal short-chain fatty acids of growing Pekin ducks. Ji, Z. Q.,Hao, Y. S.,Wang, Y. T.,Zhang, B.,Tang, J.,Huang, W.,Zhang, Q.,Hou, S. S.,Xie, M.. 2023

[20]Effects of Immobilized Antimicrobial Peptides on Growth Performance, Serum Biochemical Index, Inflammatory Factors, Intestinal Morphology, and Microbial Community in Weaning Pigs. Liu N.,Ma X.,Jiang X.. 2022

作者其他论文 更多>>