数字农科院2.0

A self-assembled graphene oxide adjuvant induces both enhanced humoral and cellular immune responses in influenza vaccine

文献类型： 外文期刊

作者： Huang S.;Li Y.;Zhang S.;Chen Y.;Su W.;Sanchez D.J.;Mai J.D.H.;Zhi X.;Chen H.;Ding X.

作者机构：

关键词： Adjuvant;Graphene oxide quantum dots;Influenza;Mass cytometry;Vaccine

期刊名称： Journal of Controlled Release

ISSN： 0168-3659

年卷期： 2024 年 365 卷

页码：

收录情况： SCIE（2024版） ; ; EI（2024版）

摘要： Antiviral vaccine is essential for preventing and controlling virus spreading, along with declining morbidity and mortality. A major challenge in effective vaccination lies in the ability to enhance both the humoral and cellular immune responses by adjuvants. Herein, self-assembled nanoparticles based on graphene oxide quantum dots with components of carnosine, resiquimod and Zn2+ ions, namely ZnGC-R, are designed as a new adjuvant for influenza vaccine. With its high capability for antigen-loading, ZnGC-R enhances antigen utilization, improves DC recruitment, and activates antigen-presenting cells. Single cell analysis of lymphocytes after intramuscular vaccination revealed that ZnGC-R generated multifaceted immune responses. ZnGC-R stimulated robust CD4+CCR7loPD-1hi Tfh and durable CD8+CD44hiCD62L- TEM immune responses, and simultaneously promoted the proliferation of CD26+ germinal center B cells. Besides, ZnGC-R elicited 2.53-fold higher hemagglutination-inhibiting antibody than commercial-licensed aluminum salt adjuvant. ZnGC-R based vaccine induced 342% stronger IgG antibody responses compared with vaccines with inactivated virus alone, leading to 100% in vivo protection efficacy against the H1N1 influenza virus challenge. © 2023

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