文献类型： 外文期刊

作者： He Jian;Lin Zhidong;Hu Xulin;Xing Luyao;Liang Gaofeng;Chen Dongliang;An Junling;Xiong Chengdong;Zhang Xiangchun;Zhang Lifang

作者机构：

关键词： Microshpere; Oleic acid-tricalcium phosphate; Polytrimethylene carbonate; Tissue engineering

期刊名称： Colloids and Surfaces B: Biointerfaces

ISSN： 0927-7765

年卷期： 2021 年 204 卷

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收录情况： JCR（2021版） ; EI（2021版）

摘要： Biocompatible polymers and drug delivery vehicles have been driving development in bone regeneration. However, most bone scaffolds show poor degradation and proliferation. In this study, a composite microsphere scaffold was prepared using vancomycin hydrochloride(VH)-loaded polytrimethylene carbonate(PTMC) microsphere (PTMC-VH). Adopting a thermal technique, a three-dimensional oleic acid-modified tricalcium phosphate (PTMC-OA-TCP)/PTMC-VH microsphere scaffold was prepared. It had a porosity of 41–47 % and pore size of 129−154 μm. The highest drug loading and release efficiency were obtained with the scaffold produced using 2.4 % polymer concentration and 0.5 %polyvinyl alcohol. The scaffold with PTMC-VH microsphereshad enhancedmechanical properties, water absorption capacity, and degradation. In addition, the PTMC-OA-TCP scaffold had comparable performance with bone cement control in terms of bone regeneration in vivo. In summary, the prepared bioactive scaffolds, which had favorable mechanical properties and facilitated osteogenesis, could be a promising alternative for bone cement in bone tissue engineering. © 2021 Elsevier B.V.

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