数字农科院2.0

Genetic distribution, characterization, and function of Escherichia coli type III secretion system 2 (ETT2)

文献类型： 外文期刊

作者： Xinyu Wang;Hong Zhu;Jiangang Hu;Beibei Zhang;Weiqi Guo;Zhiyang Wang;Di Wang;Jingjing Qi;Mingxing Tian;Yanqing Bao;Fusheng Si;Shaohui Wang

作者机构：

关键词： Bacteriology;Genetics;Microbiology

期刊名称： iScience

ISSN： 2589-0042

年卷期： 2024 年 27 卷 5 期

页码：

收录情况： SCIE（2024版）

摘要： Many Gram-negative bacteria use type Ⅲ secretion system (T3SS) to inject effector proteins and subvert host signaling pathways, facilitating the growth, survival, and virulence. Notably, some bacteria harbor multiple distinct T3SSs with different functions. An extraordinary T3SS, the Escherichia coli Type III Secretion System 2 (ETT2), is widespread among Escherichia coli (E. coli) strains. Since many ETT2 carry genetic mutations or deletions, it is thought to be nonfunctional. However, increasing studies highlight ETT2 contributes to E. coli pathogenesis. Here, we present a comprehensive overview of genetic distribution and characterization of ETT2. Subsequently, we outline its functional potential, contending that an intact ETT2 may retain the capacity to translocate effector proteins and manipulate the host's innate immune response. Given the potential zoonotic implications associated with ETT2-carrying bacteria, further investigations into the structure, function and regulation of ETT2 are imperative for comprehensive understanding of E. coli pathogenicity and the development of effective control strategies.

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