数字农科院2.0

Fe,Zr-MOF Nanozyme-Enhanced Dual-Recognition System: Integrating Molecularly Imprinted Polymers and Aptamers for Colorimetric Detection of Chlorpyrifos

文献类型： 外文期刊

作者： Yu, Chunqi;Wang, Yingqi;Wang, Ke;Zhang, Shuai;Hu, Xiaopeng;Liu, Yiwei;Xi, Jiajia

作者机构：

关键词： dual-recognition;bimetallic organic frameworks;chlorpyrifos;aptamer;molecularly imprinted polymer

期刊名称： JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN： 0021-8561

年卷期： 2025 年

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Chlorpyrifos (CPF) poses severe environmental and health risks, driving the need for on-site monitoring tools. This study presents a novel dual-recognition colorimetric sensor for ultrasensitive detection of CPF by coimmobilizing molecularly imprinted polymers (MIPs) and aptamers onto bimetallic Fe,Zr-MOF composites. The resulting Fe,Zr-MOF/Apt/MIP hybrid synergistically merges the structural robustness of MIPs with the conformational specificity of aptamers, while also functioning as both a nanocarrier and a peroxidase mimic. Notably, CPF binding sterically hinders substrate diffusion to catalytic sites, enabling quantitative detection via dose-dependent inhibition of TMB oxidation. The optimized sensor exhibits exceptional performance: a broad linear range (1-120 ng mL-1), ultralow detection limit (0.105 ng mL-1), and high specificity against interferents. When validated with complex matrices (apples, pears, and cabbage), it achieved satisfactory recoveries (91.0-110.0%). This work establishes a field-deployable strategy for on-site pesticide monitoring in food and environmental safety.

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