数字农科院2.0

Molecular pharming in maize endosperm: A proof of concept with recombinant SARS-CoV-2 antigen production

文献类型： 外文期刊

作者： Yuxin Tai;;Shujun Meng;;Yiteng Zhang;;Jianfeng Weng;;Xinhai Li;;Qingyu Wu

关键词： SARS-CoV-2; Spike; RBD; maize; molecular pharming

期刊名称： PLANT BIOTECHNOLOGY JOURNAL

ISSN： 1467-7644

年卷期： 2025 年

页码：

收录情况： SCIE（2025版）

摘要： Molecular pharming, which leverages plants to produce thera- peutic proteins, is a cost-effective, scalable and environmentally friendly method for recombinant protein production. It primarily involves expressing therapeutic proteins, such as antigens, in plants and subsequently purifying these proteins for pharmaceu- tical applications (Fausther-Bovendo and Kobinger, 2021). Early pioneers identified several key advantages of plants as molecular pharming vessels, including their low cost, scalability, safety and environmental sustainability (Zhu et al., 2022).

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