数字农科院2.0

Revealing the inhibitory effect of VASH1 on ovarian cancer from multiple perspectives

文献类型： 外文期刊

作者： Yan Li;Liang Meng;Ge Lou

作者机构：

关键词： immune cell infiltration;ovarian cancer;suppressor;tumor purity;VASH1

期刊名称： Cancer Biology and Therapy

ISSN： 1538-4047

年卷期： 2023 年 24 卷 1 期

页码：

收录情况： SCIE（2023版）

摘要： The function of Vasohibin-1 (VASH1) in human cancer has not been thoroughly or comprehensively examined. Here, we identified the tumor suppressor part of VASH1 across cancers, including epithelial ovarian tumors. Our study carefully contrasted the expression of VASH1 in pancancer and nontumorous tissues in a public database to explore its regulatory role in clinical prognosis, diagnosis, tumor purity, and immune cell infiltration. Next, we explored the antitumor mechanism of VASH1 through drug sensitivity, functional enrichment, and phenotypic experiments in ovarian cancer. Research suggests that the expression of VASH1 in neoplastic tissues is lower than that in normal tissues. VASH1 affects the OS and RFS of several tumor types. In addition, VASH1 expression resulted in a high OS and RFS in the diagnosis of tumor and nontumor tissues and negatively regulated tumor purity. Moreover, VASH1 controls the tumor microenvironment by regulating immunocyte infiltration. In ovarian cancer, VASH1 can serve as a biomarker to estimate the efficacy of chemotherapy. Functional enrichment analysis suggests that VASH1 plays a tumor suppressor role by regulating the extracellular matrix receptor pathway. VASH1 inhibition of the malignant phenotype of ovarian cancer cells was further confirmed by in vivo experiments. These results indicate that VASH1 acts as a cancer-inhibiting factor and potential therapeutic target in ovarian cancer.

分类号：

  • 相关文献

[1]Characterization of a Novel Polerovirus Infecting Maize in China. Jiang, Guangzhuang,Wu, Jianxiang,Qian, Yajuan,Zhou, Xueping,Jiang, Guangzhuang,Zhou, Xueping,Liu, Yong. 2016

[2]P25 and P37 proteins encoded by firespike leafroll-associated virus are viral suppressors of RNA silencing. Wang Y.,Liu H.,Wang Z.,Guo Y.,Hu T.,Zhou X.. 2022

[3]Molecular Variation and Genomic Function of Citrus Vein Enation Virus. Runqiu Dou,Qingqing Huang,Tao Hu,Fengzhe Yu,Hongxia Hu,Yaqin Wang,Xueping Zhou,Yajuan Qian. 2023

[4]Identification Of The Potential Virulence F.actors And Rna Silencing S uppressors Of Mulberry Mosaic Dwarf-Associated Geminivirus. Yang, XL,Ren, YX,Sun, SS,Wang, DX,Zhang, FF,Li, DW,Li, SF,Zhou, XP. 2018

[5]Silencing of BAG3 promotes the sensitivity of ovarian cancer cells to cisplatin via inhibition of autophagy. Qiu, Shuang,Jin, Ye,An, Qi,Zheng, Jianhua,Sun, Liang,Weng, Changjiang.

[6]Inhibitory Effects of Total Triterpenoid Saponins Isolated from the Seeds of the Tea Plant (Camellia sinensis) on Human Ovarian Cancer Cells. Jia, Ling-Yan,Wu, Xue-Jin,Li, Bo,Tu, You-Ying,Jia, Ling-Yan,Pigliacampi, Alexa,Bucur, Heather,Chen, Yi Charlie,Gao, Ying,Rankin, Gary O..

[7]Wnt5a as a Predictor in Poor Clinical Outcome of Patients and a Mediator in Chemoresistance of Ovarian Cancer. Peng, Chunjie,Zhang, Xiaolei,Yu, Hongli,Zheng, Jianhua,Wu, Donglai. 2011

[8]Investigation Of Hypoxia Networks In O.varian Cancer Via Bioinformatics A nalysis. Zhang, K, Kong, XJ, Feng, GD, Xiang, W, Chen, L, Yang, F, Cao, CY, Ding, YF, Chen, H, Chu, MX, Wang, PQ, Zhang, BY. 2018

[9]Silencing Of Bag3 Promotes The S.ensitivity Of Ovarian Cancer C ells To Cisplatin Via Inhibition Of Autophagy. Qiu, S, Sun, L, Jin, Y, An, Q, Weng, CJ, Zheng, JH. 2017

[10]METTL3-mediated m6A methylation regulates ovarian cancer progression by recruiting myeloid-derived suppressor cells. Jinyong Wang,Dakai Ling,Lulin Shi,Huayun Li,Minhua Peng,Huihong Wen,Tao Liu,Ruifang Liang,Yongjian Lin,Laiyou Wei,Guangzhi Zhang,Shanze Chen. 2023

作者其他论文 更多>>