数字农科院2.0

Regulation of plant immunity through histone H3 β-hydroxybutyrylation-mediated transcriptional control

文献类型： 外文期刊

作者： 徐秋涛;;陈正庭;;王瑞;;;;马瑄;;;;段宇航;;;;海杜;;;;陈静;;;;程仲毅;;;;郑路;;;;黄俊斌;;;;张积森;;;;赵毓;;;;陈晓洋

作者机构：

关键词： 水稻免疫;;;;组蛋白H3 β羟基化修饰;;;;转录调控

期刊名称： Nature Communications

ISSN：

年卷期： 2025 年

页码：

收录情况： SCIE（2025版）

摘要： 组蛋白赖氨酸β-羟基丁酰化（Kbhb）是一种新型组蛋白酰化修饰，其在植物中的分布与功能尚不明确。本研究系统分析了水稻中H3K9bhb修饰特征，发现该修饰富集在转录起始位点区域，可作为基因表达的活性标记。我们证实了H3K9bhb与已充分研究的H3K9ac修饰存在功能差异，尤其在调控水稻免疫应答相关基因方面。实验表明外源施加β-羟基丁酸可诱导H3K9bhb沉积，促进防御相关基因表达并增强病害抗性。此外，鉴定出OsSRT1、OsSRT2和OsHDA705是去除Kbhb修饰的关键酶。通过Kbhb蛋白质组学分析，在1128个蛋白上鉴定到2159个Kbhb修饰位点，为后续研究提供了重要资源。本研究通过确立Kbhb作为调控植物免疫应答的潜在翻译后修饰机制，推进了植物表观遗传调控领域的认知。

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