数字农科院2.0

Antibiotic resistance profile of nitrogen-metabolizing microbes in anoxic-oxic processes for swine wastewater treatment

文献类型： 外文期刊

作者： Yang, Yiwen;Cai, Shuang;Huang, Feng;Mo, Chunhao;Wu, Yongbao;Cao, Junting;Chen, Sheng;Wen, Zhiguo;Liao, Xindi

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期刊名称： NPJ CLEAN WATER

ISSN： 2059-7037

年卷期： 2025 年 8 卷 1 期

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收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： The anoxic-oxic (A/O) process is the most common biological method for removing nitrogen (N) from wastewater, but the antibiotic resistance profile of N-metabolizing microbes in A/O processes remains largely underexplored. Here we demonstrated a significant positive correlation between various types of N-metabolizing genes and antibiotic resistance genes (ARGs) in swine wastewater A/O processes across China. We assembled 180 high-quality genomes of dominant N-metabolizing microbes (12.6% of the total metagenome-assembled genomes), all harboring transcriptionally active ARGs. And Pseudomonas was identified as the primary N-metabolizing genus and major ARG host. Among 1110 culturable N-metabolizing isolates, 22.34% were Pseudomonas strains showing high N removal capacity and multi-antibiotic resistance. Moreover, plasmid-mediated ARG transfer further heightened resistance risks. Overall, these findings highlight a significant ARG risk among predominant N-metabolizing microbes in A/O treatment processes, underscoring the urgency of balancing N removal performance with resistance control in wastewater treatment processes.

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