数字农科院2.0

In vivo dynamics and regulation of DNA G-quadruplex structures in mammals

文献类型： 外文期刊

作者： Ze Hao Zhang;Sheng Hu Qian;Dengguo Wei;Zhen Xia Chen

作者机构：

关键词： Dynamic regulation;G-quadruplex;Identification and characterization;Therapeutic applications

期刊名称： Cell and Bioscience

ISSN： 2045-3701

年卷期： 2023 年 13 卷 1 期

页码：

收录情况： SCIE（2023版）

摘要： G-quadruplex (G4) is a four-stranded helical DNA secondary structure formed by guanine-rich sequence folding, and G4 has been computationally predicted to exist in a wide range of species. Substantial evidence has supported the formation of endogenous G4 (eG4) in living cells and revealed its regulatory dynamics and critical roles in several important biological processes, making eG4 a regulator of gene expression perturbation and a promising therapeutic target in disease biology. Here, we reviewed the methods for prediction of potential G4 sequences (PQS) and detection of eG4s. We also highlighted the factors affecting the dynamics of eG4s and the effects of eG4 dynamics. Finally, we discussed the future applications of eG4 dynamics in disease therapy.

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