数字农科院2.0

Dual-mode fluorescence/colorimetric aptasensor based on Zn,Ce-MOF nanocomposite for sensitive detection of isocarbophos

文献类型： 外文期刊

作者： Yimeng Li;Jiayao Wang;Yi Ran;Yiwei Liu;Xiaopeng Hu

作者机构：

关键词： Aptamer;Colorimetric;Fluorescence;Isocarbophos;MOF

期刊名称： Analytica Chimica Acta

ISSN： 0003-2670

年卷期： 2025 年 1379 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Background: A dual-mode fluorescence/colorimetric aptasensor was developed for the sensitive detection of isocarbophos, an organophosphorus pesticide posing significant public health risks. Using Zn,Ce-MOF nanocomposites, this sensor integrated magnetic separation and signal amplification. This integrated biosensing strategy offers a promising tool for environmental safety assurance and food quality control applications. Results: The Zn,Ce-MOF nanozyme of this sensor serves as both a carrier of 3,3′,5,5′-tetramethylbenzidine (TMB) and oxidase mimic, facilitating enzyme-free TMB oxidation. The dual-readout system enables self-validating detection through independent channels (fluorescence LOD: 0.06 ng mL−1; colorimetric LOD: 0.09 ng mL−1), with robust performance, high interferent selectivity, and reproducibility. Practical validation in spiked agricultural samples yielded recovery rates of 97.7–113.6 %, confirming the platform's suitability for field-deployable pesticide monitoring. Significance: This work developed a fluorescence/visual aptasensor with self-assembled TMB/Au/Zn,Ce-MOF probes for one-step magnetic separation dual-mode detection. This integrated biosensing strategy improves detection efficiency and accuracy, offering a general strategy for multimodal biosensors.

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