数字农科院2.0

Pregnancy-associated decrease of Siaα2-3Gal-linked glycans on salivary glycoproteins affects their binding ability to avian influenza virus

文献类型： 外文期刊

作者： Li Ding;Xinle Fu;Wei Guo;Yimin Cheng;Xiangqin Chen;Kun Zhang;Guang Zhu;Fuying Yang;Hanjie Yu;Zhuo Chen;Xilong Wang;Xiurong Wang;Xiaohong Wang;Zheng Li

作者机构：

关键词： Avian influenza virus (AIV);Pregnant women;Salivary glycoprotein

期刊名称： International Journal of Biological Macromolecules

ISSN： 0141-8130

年卷期： 2021 年 184.0 卷

页码：

收录情况： JCR（2021版）

摘要： Salivary glycoproteins are known as an important barrier to inhibit influenza infection by presenting sialic acid (Sia) ligands that can bind with viral hemagglutination. Here, to further understand why pregnant women are more vulnerable to avian influenza virus (AIV), we investigated the alteration of protein sialylation in the saliva of women during pregnancy and postpartum, and its impact on the saliva binding affinity to AIV. Totally 1200 saliva samples were collected, the expression levels of terminal α2-3/6-linked Sia on salivary proteins were tested and validated, and the binding activities of salivary proteins were assessed against 3 strains of AIV and the H1N1 vaccine. Result showed that the expression of terminal α2-3-linked Sia in the saliva of women decreased dramatically during pregnancy compared to that of non-pregnancy control, especially for women in the second or third trimester (fold change = 0.53 and 0.37, p < 0.001). And their salivary protein binding ability to AIV declined accordingly. The variation of terminal α2-3-linked Sia on salivary MUC5B and IgA was consistent with the above results. This study indicates that the decrease of terminal α2-3-linked Sia on salivary glycoproteins of pregnant women affects their binding ability to AIV, which may provide new insights into AIV prevention and control.

分类号：

  • 相关文献

[1]Seroprevalence of Hepatitis E Virus Among Pregnant Women and Control Subjects in China. Cong, Wei,Chen, Jia,Zhu, Xing-Quan,Cong, Wei,Qian, Ai-Dong,Zhu, Xing-Quan,Sui, Jian-Chao,Zhang, Xiang-Yan.

[2]High Expression Level of α2-3-Linked Sialic Acids on Salivary Glycoproteins of Breastfeeding Women May Help to Protect Them from Avian Influenza Virus Infection. Li Ding,Yimin Cheng,Wei Guo,Siyue Sun,Xiangqin Chen,Tiantian Zhang,Hongwei Cheng,Jiayue Hao,Yunhua Lu,Xiurong Wang,Zheng Li. 2022

[3]Development Of A Reverse-Transcription Loop-Mediated I.sothermal Amplification Assay To D etect Avian Influenza Viruses In Clinical Specimens. Shi, L, Yu, XW, Yao, W, Yu, BL, He, LK, Gao, Y, Zhang, YX, Tian, GB, Ping, JH, Wang, XR. 2019

[4]Genetic characterization and receptor binding analysis of a novel H5N1 HPAI virus with a H6Nx-derived PA gene in Guangdong, China. Jieheng He,Jing Liu,Zhanfei Yan,Gaojie Chen,Runzhi Liu,Yu Yang,Yulin Yan,Sheng Yuan,Jinyue Guo,Yong Li,Hai Yu,Zhaoping Liang,Tao Ren,Shujian Huang,Feng Wen. 2024

作者其他论文 更多>>