数字农科院2.0

pH-driven plant protein nanoparticles modulated by flaxseed gum oligosaccharides for apigenin delivery

文献类型： 外文期刊

作者： Ziliang Li;;Yufei Liu;;Shuaijun Lu ;;Shang Gao ;; Li Chen ;; Qianchun Deng;; Zhenxia Xu;;Xia Xiang

关键词： FGOS;;Plant protein;;Apigenin;;Bioavailability;;Mechanism

期刊名称： Food Chemistry

ISSN： 0308-8146

年卷期： 2025 年

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Polysaccharide-modulated plant protein nanoparticles offer a promising strategy for polyphenol delivery. In this study, flaxseed gum oligosaccharides (FGOS) were used to modify apigenin (Ap)-loaded nanoparticles assembled from perilla (PPI), flaxseed (FPI), and sesame (SPI) protein isolates via a pH-driven method, forming FGOS/PPI@Ap, FGOS/FPI@Ap, and FGOS/SPI@Ap. FGOS coating reduced particle size and increased surface charge, enhancing encapsulation efficiency, antioxidant activity, and stability. In these three nanoparticles, FGOS/PPI@Ap exhibited superior performance in encapsulation, in vitro sustained release, and significantly improved bioaccessibility and oral bioavailability. Fluorescence quenching, molecular docking, and molecular dynamics simulations revealed stronger Ap-PPI interactions mediated by hydrogen bonding, hydrophobic, and electrostatic forces. Pharmacokinetic results further validated the in vivo delivery advantages of FGOS/PPI@Ap. This work provides insight into FGOS-protein-polyphenol ternary systems and identifies FGOS as a stabilizing agent and PPI as an efficient protein-based carrier for enhancing polyphenol delivery in functional foods.

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