数字农科院2.0

Novel Antibiotic-Derived Silicon Dots with Broad-Spectrum Antibacterial Activity and Efficient Wound Healing Promotion

文献类型： 外文期刊

作者： Mao, Guobin;Yin, Wen;Yang, Yeling;Zeng, Yuan;Zhou, Jie;Li, Jia-Ao;Wan, Yanhui;Zhou, Wenhua;Yu, Xue-Feng;Dai, Junbiao;Ma, Yingxin

作者机构：

关键词： antibacterial mechanism;antimicrobial drug resistance;broad-spectrum antibacterial;silicon dots;wound healing

期刊名称： SMALL

ISSN： 1613-6810

年卷期： 2025 年

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： The escalating threat of antimicrobial resistance poses a critical challenge to global health. Silicon-based nanomaterials, with their unique physicochemical properties, have recently emerged as promising agents in the development of novel antibacterial strategies. This study reports the successful synthesis of silicon nanodots with potent antibacterial activity, prepared using a combination of silane precursors and antibiotics. Nanodots generated from the silane DAMO and gentamicin (referred to as DAG-Si Ds) exhibited strong broad-spectrum antibacterial efficacy while displaying a low propensity to induce bacterial resistance. Mechanistic investigations revealed that DAG-Si Ds exert their antibacterial effects by disrupting bacterial membranes and binding to, as well as degrading, genomic DNA. In vivo studies further demonstrated that DAG-Si Ds significantly reduced bacterial burden at infection sites and promoted wound healing. Similarly, the release of SiO3 2- ions is observed to increase angiogenesis, contributing to tissue repair. DAG-Si Ds displayed minimal cytotoxicity and negligible systemic toxicity. These findings highlight DAG-Si Ds as a promising antibacterial platform and provide a foundation for the development of next-generation anti-infective strategies.

分类号：

  • 相关文献

[1]Accelerated wound-healing capabilities of a dressing fabricated from silkworm cocoon. Yu, Kun,Lu, Fei,Li, Qing,Zou, Yini,Lu, Bitao,Liu, Jiawei,Dai, Fangying,Wu, Dayang,Lan, Guangqian,Lu, Fei,Dai, Fangying,Wu, Dayang,Lan, Guangqian,Xiao, Yang.

[2]Positively Charged Carbon Dots with Antibacterial and Antioxidant Dual Activities for Promoting Infected Wound Healing. Qu, Xiaoqing,Gao, Chenxi,Fu, Lei,Chu, Yuefeng,Wang, Jian-Hua,Qiu, Hongdeng,Chen, Jia. 2023

[3]Substances for regenerative wound healing during antler renewal stimulated scar-less restoration of rat cutaneous wounds. Qianqian Guo,Zhen Liu,Junjun Zheng,Haiping Zhao,Chunyi Li. 2021

[4]Pnpla5-knockout rats exhibit reduced expression levels of proteins involved in steroid metabolism and wound healing compared to wild-type rats. Liu Z.-G.,Hu Y.-Q.,Li K.,Mu Y.-L.,Wu T.-W.. 2022

[5]Human Amniotic Fluid Stem Cell-Derived Exosomes as a Novel Cell-Free Therapy for Cutaneous Regeneration. Yan Zhang,Jiaqing Yan,Yanhong Liu,Zhenyu Chen,Xiheng Li,Liang Tang,Jiang Li,Mengna Duan,Guokun Zhang. 2021

[6]Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition. Yan Zhang,Yingjin Pan,Yanhong Liu,Xiheng Li,Liang Tang,Mengna Duan,Jiang Li,Guokun Zhang. 2021

[7]Velvet Antler Peptides Reduce Scarring via Inhibiting the TGF-β Signaling Pathway During Wound Healing. Guokun Zhang,Dongxu Wang,Jing Ren,Hongmei Sun,Jiping Li,Shengnan Wang,Liyan Shi,Zhen Wang,Mengjie Yao,Haiping Zhao,Chunyi Li. 2022

[8]Antibacterial peptide NZ2114-loaded hydrogel accelerates Staphylococcus aureus-infected wound healing. Huang, Yan,Yang, Na,Teng, Da,Mao, Ruoyu,Hao, Ya,Ma, Xuanxuan,Wei, Lingyun,Wang, Jianhua. 2022

[9]CCL3 Promotes Cutaneous Wound Healing Through Recruiting Macrophages in Mice. Wanwan Shi,Xunsheng Li,Zhen Wang,Chenguang Li,Datao Wang,Chunyi Li. 2024

[10]A novel pH/ROS dual responsive engineering hydrogels based on poly(tannic acid)-assisted surface deposition of nano-enzymes with efficient antibacterial and antioxidant activity for diabetic wound healing. Hongyu Li,Yingping Wang,Xiance Che,Lanping Guo,Luqi Huang,Xia Li,Wenyuan Gao. 2024

[11]Comparative Efficacy of Zinc Oxide Nanoparticles and Citric Acid on Surgically Incised Wound in Rabbit. Rizwan Abdul Aleem,Asad Khan,Shafqat Naeem,Muhammad Tahir Aleem,Iftikhar Ali Khan,Abdul Qadeer,Shakeel Ahmed,Sadaf Aslam,Ashar Mehfooz. 2025

[12]The combination treatment of low voltage electrostatic field and Ultraviolet-C could accelerate the process of wound healing of potato tubers. Xingxing He,Tingting Zhang,Fengling Wang,Wenqiang Guan,Qiong Lin,Xiulan Sun. 2024

[13]Latest advance anti-inflammatory hydrogel wound dressings and traditional Lignosus rhinoceros used for wound healing agents. Safia Arbab,Hanif Ullah,Nehaz Muhammad,Weiwei Wang,Jiyu Zhang. 2024

[14]Development of mint essential oil based-nanosprays loaded with curcumin and β-carotene for accelerating wound healing. Shiru Bai,Lu Tang,Dan Zhao,Bo Wang,Bei Fan,Liang Zhang,Fengzhong Wang. 2025

[15]Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis. Hu, Ya-Zhen,Wang, Ting,Wu, Chang-Song,Wang, Jie,Han, Xue-Qing,Zhang, Yong-An,Zhang, Xu-Jie. 2025

[16]Extract of Syringa oblata: A new biocontrol agent against tobacco bacterial wilt caused by Ralstonia solanacearum. Bai, Wanming,Kong, Fanyu,Zhang, Chengsheng,Bai, Wanming,Lin, Yong.

[17]Efficient antibacterial agents: A review of the synthesis, biological evaluation and mechanism of pleuromutilin derivatives. Shang, Ruofeng,Guo, Wenzhu,Liang, Jianping,Wang, Jiatu.

[18]Mechanism of action of the tri-hybrid antimicrobial peptide LHP7 from lactoferricin, HP and plectasin on Staphylococcus aureus. Xi, Di,Wang, Xiumin,Teng, Da,Mao, Ruoyu,Zhang, Yong,Wang, Xiaojie,Wang, Jianhua,Xi, Di,Wang, Xiumin,Teng, Da,Mao, Ruoyu,Zhang, Yong,Wang, Xiaojie,Wang, Jianhua,Xi, Di.

[19]Inhibitory Effect of Camptothecin against Rice Bacterial Brown Stripe Pathogen Acidovorax avenae subsp avenae RS-2. Dong, Qiaolin,Cai, Li,Hou, Mingsheng,Luo, Ju,Qiu, Wen,Anjum, Syed Ishtiaq,Li, Bin,Xie, Guanlin,Anjum, Syed Ishtiaq,Sun, Guochang.

[20]Novel xanthone antibacterials: Semi-synthesis, biological evaluation, and the action mechanisms. Yan Lu,Ting Guan,Shaobing Wang,Cui Zhou,Meizhu Wang,Xiaoyang Wang,Keyu Zhang,Xiangan Han,Jinchao Lin,Qun Tang,Chunmei Wang,Wen Zhou. 2023

作者其他论文 更多>>