数字农科院2.0

Genome-wide selection signal analysis reveals the adaptability of Tibetan sheep to high altitudes

文献类型： 外文期刊

作者： Song, Yufang;Yuan, Chao;Guo, Tingting;Chen, Bowen;Wang, Fan;Lu, Zengkui;Liu, Jianbin

作者机构：

关键词： Tibetan sheep;high-altitude adaptation;whole-genome resequencing;Fst;theta pi ratio;selection signal

期刊名称： FRONTIERS IN VETERINARY SCIENCE

ISSN：

年卷期： 2025 年 12 卷

页码：

收录情况： SCIE（2025版）

摘要： Altitude adaptation is a complex process involving multiple physiological and biochemical responses to hypoxia and other environmental stresses. In-depth genetic analysis of Tibetan sheep, which exhibit significant adaptations to high-altitude hypoxia, promises to elucidate hypoxia-tolerance mechanisms in plateau animals. Here, we conducted a genome-wide selection scan on three Tibetan sheep populations: low-altitude Tao (TS; 2887 m), medium-altitude Tianjun white (WT; 3331 m), and high-altitude Huoerba (HB; 4614 m). Using the population differentiation index (Fst) and nucleotide diversity (theta pi) ratio, we analyzed selection signals associated with hypoxia at high-altitudes. We screened 865, 941, and 876 candidate genes in the TS vs. WT, TS vs. HB, and WT vs. HB group comparisons, respectively, 55 of which were jointly screened. Integrated analysis further identified several key pathways and genes under positive selection in Tibetan sheep populations, including metabolic pathways (GSTA1, ALAS1, HMOX2, SCD, ME1, ACSL6, PIK3C2G), melanogenesis (MITF, EP300), and the HIF-1 signaling pathway (ERBB2, HIF1A, RELA). Among these, the metabolic pathways may enhance energy production under hypoxic conditions, while melanogenesis and the HIF-1 signaling pathway are likely associated with ultraviolet radiation protection and hypoxia tolerance, respectively. This study provides valuable insights into the genetic mechanism of high-altitude adaptation in Tibetan sheep, and also provides important theoretical basis for the conservation and breeding of Tibetan sheep and the sustainable development of plateau animal husbandry.

分类号：

  • 相关文献

[1]Genome-Wide Selection Signals Reveal Candidate Genes Associated with Plateau Adaptation in Tibetan Sheep. Yufang Song,Chao Yuan,Xuejiao An,Tingting Guo,Wentao Zhang,Zengkui Lu,Jianbin Liu. 2024

[2]Whole genome re-sequencing reveals artificial and natural selection for milk traits in East Friesian sheep. Li X.,Yuan L.,Wang W.,Zhang D.,Zhao Y.,Chen J.,Xu D.,Zhao L.,Li F.,Zhang X.. 2022

[3]Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness. Wentao Zhang,Meilin Jin,Taotao Li,Zengkui Lu,Huihua Wang,Zehu Yuan,Caihong Wei. 2023

[4]Genomic Insights into Tibetan Sheep Adaptation to Different Altitude Environments. Wentao Zhang,Chao Yuan,Xuejiao An,Tingting Guo,Caihong Wei,Zengkui Lu,Jianbin Liu. 2024

[5]Analysis of Migration and Adaptive Evolution in Tibetan Sheep Populations. Wentao Zhang,Chao Yuan,Tingting Guo,Bowen Chen,Fan Wang,Jianbin Liu,Zengkui Lu. 2026

[6]德保矮马X染色体选择信号筛选. 刘雪雪,阿地力江·卡德尔,董坤哲,王月月,潘建飞,浦亚斌,何晓红,马月辉,蒋琳. 2015

[7]全基因组选择信号揭示绒山羊绒毛性状相关的候选基因. 金美林,陆健,费晓娟,卢曾奎,权凯,储明星,狄冉,王慧华,魏彩虹. 2020

[8]全基因组选择信号揭示绵羊毛囊发育及脱毛性状相关的候选基因. 雷志惠,张利平,赵洪昌,朱韶华,卢曾奎,郭婷婷,孙渭博,赫雪,岳耀敬. 2022

[9]Genetic parameters estimation and genome molecular marker identification for gestation length in pigs. Lijun Shi,Huihui Li,Lixian Wang. 2023

[10]Synthesis and antibacterial activity of FST and its effects on inflammatory response and intestinal barrier function in mice infected with Escherichia coli O78. Ge W.,Li Z.,Yang Y.,Liu X.,Zhu Z.,Bai L.,Qin Z.,Xu X.,Li J.,Li S.. 2024

[11]Resequencing and Signatures of Selective Scans Point to Candidate Genetic Variants for Hair Length Traits in Long-Haired and Normal-Haired Tianzhu White Yak. Qi Bao,Xiaoming Ma,Congjun Jia,Xiaoyun Wu,Yi Wu,Guangyao Meng,Pengjia Bao,Min Chu,Xian Guo,Chunnian Liang,Ping Yan. 2022

[12]Association of novel single-nucleotide polymorphisms of the vascular endothelial growth factor-A gene with high-altitude adaptation in yak (Bos grunniens). Wu, X. Y.,Liang, C. N.,Ding, X. Z.,Guo, X.,Bao, P. J.,Chu, M.,Liu, W. B.,Yan, P.,Wu, X. Y.,Liang, C. N.,Ding, X. Z.,Guo, X.,Bao, P. J.,Chu, M.,Liu, W. B.,Yan, P.. 2013

[13]Chromosome-level genome assemblies of four wild peach species provide insights into genome evolution and genetic basis of stress resistance. Cao, Ke,Peng, Zhen,Zhao, Xing,Li, Yong,Liu, Kuozhan,Arus, Pere,Fang, Weichao,Chen, Changwen,Wang, Xinwei,Wu, Jinlong,Fei, Zhangjun,Wang, Lirong. 2022

[14]Comparative Transcriptome Analysis of Gayal (Bos frontalis), Yak (Bos grunniens), and Cattle (Bos taurus) Reveal the High-Altitude Adaptation. Jun Ma,Tianliu Zhang,Wenxiang Wang,Yan Chen,Wentao Cai,Bo Zhu,Lingyang Xu,Huijiang Gao,Lupei Zhang,Junya Li,Xue Gao. 2022

[15]Integrative Genomic, Transcriptomic and Epigenomic Analysis Reveals cis-regulatory Contributions to High-Altitude Adaptation in Tibetan Pigs. Dingwang Lai,Xiaolu Qu,Zhen Wang,Sang He,Xingzheng Li,Qi Bao,Guangming Sun,Jian Zhang,Yanbin Zhu,Guoqiang Yi. 2025

[16]Recent selection and introgression facilitated high-altitude adaptation in cattle. Lyu, Yang,Wang, Fuwen,Cheng, Haijian,Han, Jing,Dang, Ruihua,Xia, Xiaoting,Wang, Hui,Zhong, Jincheng,Lenstra, Johannes A.,Zhang, Hucai,Han, Jianlin,Machugh, David E.,Medugorac, Ivica,Upadhyay, Maulik,Leonard, Alexander S.,Ding, He,Yang, Xiaorui,Wang, Ming-Shan,Quji, Suolang,Zhuzha, Basang,Quzhen, Pubu,Wangmu, Silang,Cangjue, Nima,Wa, Da,Ma, Weidong,Liu, Jianyong,Zhang, Jicai,Huang, Bizhi,Qi, Xingshan,Li, Fuqiang,Huang, Yongzhen,Ma, Yun,Wang, Yu,Gao, Yuanpeng,Lu, Wenfa,Lei, Chuzhao,Chen, Ningbo. 2024

[17]Insight into the meat quality differences of Tibetan sheep from different altitudes based on metabolomics. Ruisi Liu,Jianing Fu,Shaobo Li,Minghui Gu,Liang Li,Le Xu,Jiangying Yu,Dequan Zhang,Li Chen. 2026

[18]Development of InDel markers for the restorer gene and Rf1 assessment of their utility for marker-assisted selection in cotton. Jianyong Wu,Meng Zhang,Xuexian Zhang,Liping Guo,Tingxiang Qi,Hailin Wang,Huini Tang,Jinfa Zhang,Chaozhu Xing.

[19]Whole-genome resequencing reveals molecular imprints of anthropogenic and natural selection in wild and domesticated sheep. Zhang D.-Y.,Zhang X.-X.,Li F.-D.,Yuan L.-F.,Li X.-L.,Zhang Y.-K.,Zhao Y.,Zhao L.-M.,Wang J.-H.,Xu D.,Cheng J.-B.,Yang X.-B.,Li W.-X.,Lin C.-C.,Zhou B.-B.,Wang W.-M.. 2022

[20]Inheritance And Gene Mapping Of S.potted To Non-Spotted Trait G ene Cmsp-1 In Melon (Cucumis Melo L. Var. Chinensis Pangalo). Lv, JC, Fu, QS, Lai, Y, Zhou, MD, Wang, HS. 2018

作者其他论文 更多>>