数字农科院2.0

A Major Facilitator Superfamily Transporter Is Critical for the Metabolism and Biogenesis of the Apicoplast

文献类型： 外文期刊

作者： Liang, Yumeng;Qi, Wei;Fu, Jiawen;Jia, Honglin

作者机构：

关键词： Toxoplasma gondii;apicoplast;MFS transporter;metabolic activity;biogenesis

期刊名称： PATHOGENS

ISSN：

年卷期： 2025 年 14 卷 8 期

页码：

收录情况： SCIE（2025版）

摘要： The apicoplast is a highly specialized organelle in the biosynthesis of essential metabolites in most of the apicomplexan protozoa. This organelle is surrounded by four layers of membranes. However, the molecular mechanisms mediating transmembrane transport are not yet fully understood. In this study, we conducted a phenotypic analysis to investigate the role of a major facilitator superfamily transporter (TgApMFS1) in the survival of the parasite. The results indicated that TgApMFS1 is critical for the survival of Toxoplasma gondii in cell culture conditions. Further analysis indicated that these transporters are crucial for the biogenesis of organelles and the metabolic processes of parasite.

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