数字农科院2.0

Recent advances in surface-modified liposomes with polysaccharides for bioactive delivery

文献类型： 外文期刊

作者： Chunlei Ni;Qiuhong Liao;Ruifeng Ying;Khizar Hayat;Ahmad Mohammad Salamatullah;Meigui Huang

作者机构：

关键词： Controlled release;Liposome;Polysaccharide;Stability;Surface modification

期刊名称： Food Chemistry

ISSN： 0308-8146

年卷期： 2025 年 492 卷

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： Liposomes have been widely employed as delivery systems, whereas they suffer from some drawbacks such as low encapsulation efficiency, poor stability during storage and under gastrointestinal tract, and lack of controlled release. To solve these issues, the surface chemistry of liposome technology started by modifying the liposomal surface with different ligands. This review article summarizes the emerging trends in surface-modified liposomes with polysaccharides for delivery of bioactive compounds. The polysaccharides that have been used for liposome surface modification include chitosan and its derivatives, pectin, hyaluronic acid, cellulose, and polysaccharide gums. The strategies of polysaccharide modification, stabilizing mechanisms, advantages and limitations of each of the polysaccharide, and food application are discussed. The combinations of polysaccharides for the production of double-layered liposomes are also highlighted.

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