Product of natural evolution (SARS, MERS, and SARS-CoV-2); deadly diseases, from SARS to SARS-CoV-2
文献类型： 外文期刊
作者： Shahrajabian, Mohamad Hesam;Sun, Wenli;Cheng, Qi;Cheng, Qi;Cheng, Qi
作者机构：
关键词： SARS; coronaviruses; SARS-CoV-2; MERS; pneumonia; emerging diseases
期刊名称： HUMAN VACCINES & IMMUNOTHERAPEUTICS
ISSN： 2164-5515
年卷期：
页码：
收录情况： SCI
摘要： SARS-CoV-2, the virus causing COVID-19, is a single-stranded RNA virus belonging to the order Nidovirales, family Coronaviridae, and subfamily Coronavirinae. SARS-CoV-2 entry to cellsis initiated by the binding of the viral spike protein (S) to its cellular receptor. The roles of S protein in receptor binding and membrane fusion makes it a prominent target for vaccine development. SARS-CoV-2 genome sequence analysis has shown that this virus belongs to the beta-coronavirus genus, which includes Bat SARS-like coronavirus, SARS-CoV and MERS-CoV. A vaccine should induce a balanced immune response to elicit protective immunity. In this review, we compare and contrast these three important CoV diseases and how they inform on vaccine development.
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