数字农科院2.0

Oncolytic virus and immunogenic cell death in cancer therapy

文献类型： 外文期刊

作者： Cao, Guoxiu;Ding, Chan;Dai, Jun;Qiu, Xusheng

作者机构：

关键词： Oncolytic viruses;Immunogenic cell death;Cancer;Therapy

期刊名称： TUMOUR VIRUS RESEARCH

ISSN： 2666-6790

年卷期： 2025 年 20 卷

页码：

收录情况： ESCI（2025版）

摘要： As a promising cancer treatment strategy, oncolytic viruses (OVs) selectively replicate and kill tumor cells while sparing normal cells. They improve the tumor immunosuppressive microenvironment through multiple mechanisms, including direct infection, replication, and lysis of tumor cells-leading to the release of tumorassociated antigens (TAAs), chemokines, and cytokines, which in turn induce immunogenic cell death (ICD) and trigger sustained antitumor immune responses. Currently, while OVs have demonstrated therapeutic efficacy in multiple preclinical and clinical studies, their monotherapy fails to benefit a broad spectrum of cancer patients. Therefore, there remains a need to fully understand the biological mechanisms of OVs and optimize immunotherapeutic strategies to benefit more cancer patients and enhance therapeutic efficacy. In this review, we discuss how the immune responses induced by OVs maintain a balance between antiviral and antitumor immunity, as well as their unique characteristics in inducing ICD. In addition, we describe how to enhance the efficacy of cancer immunotherapy by combining OVs therapy with ICD inducers, aiming to provide valuable insights to guide the development of clinical OVs -based therapies.

分类号：

  • 相关文献

[1]Gut microbiota therapy in gastrointestinal diseases. Ullah, Hanif,Arbab, Safia,Chang, Chengting,Bibi, Saira,Muhammad, Nehaz,Rehman, Sajid Ur,Suleman, Irfan,Ullah, Irfan,Ul Hassan, Inam,Tian, Yali,Li, Ka. 2025

[2]Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells. Sun, Yifan,Tang, Lanlan,Kan, Xianjin,Tan, Lei,Song, Cuiping,Qiu, Xusheng,Liao, Ying,Nair, Venugopal,Ding, Chan,Liu, Xiufan,Sun, Yingjie. 2024

[3]MicroRNAs: Potentially important regulators for schistosome development and therapeutic targets against schistosomiasis. Cheng, Guofeng,Jin, Youxin,Jin, Youxin. 2012

[4]Coronavirus Infection and Cholesterol Metabolism. Jun Dai,Huan Wang,Ying Liao,Lei Tan,Yingjie Sun,Cuiping Song,Weiwei Liu,Xusheng Qiu,Chan Ding. 2022

[5]Specific Monoclonal Antibodies Targeting Unique HA Epitopes Block H7N9 Influenza A Viral Replication. Shen, Wentao,Wang, Qian,Wang, Zhengxiang,Liu, Minxuan,Du, Yingying,Yuan, Lvfeng,Han, Lu,Smietanka, Krzysztof,Chen, Hualan,Xu, Shuai,Zhu, Qiyun. 2022

[6]A synthetic toll-like receptor 7 agonist inhibits porcine reproductive and respiratory syndrome virus replication in piglets. Qiuping Huang,Haoyan Yang,Dingfan Yang,Yuanjie Hao,Shijia Yu,Zhongyi Guo,Lingyujia Tian,Xuehui Cai,Baicheng Huang,Angke Zhang,Gang Wang,Taofeng Du. 2022

[7]Coronavirus Porcine Epidemic Diarrhea Virus Utilizes Chemokine Interleukin-8 to Facilitate Viral Replication by Regulating Ca2+ Flux. Guo, Xuyang,Feng, Yingtong,Zhao, Xiaojing,Qiao, Shuang,Ma, Zhiqian,Li, Zhiwei,Zheng, Haixue,Xiao, Shuqi. 2023

[8]Interplays of liver fibrosis-associated microRNAs: Molecular mechanisms and implications in diagnosis and therapy. Li, Hong,Liu, Tingli,Yang, Yongchun,Cho, William C.,Flynn, Robin J.,Harandi, Majid Fasihi,Song, Houhui,Luo, Xuenong,Zheng, Yadong. 2023

[9]Antimicrobial resistance of Pseudomonas aeruginosa: navigating clinical impacts, current resistance trends, and innovations in breaking therapies. Elfadadny A.,Ragab R.F.,AlHarbi M.,Badshah F.,Ibáñez-Arancibia E.,Farag A.,Hendawy A.O.,De los Ríos-Escalante P.R.,Aboubakr M.,Zakai S.A.,Nageeb W.M.. 2024

[10]Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation. Zheng, Jiangge,Lang, Yue,Zhang, Qi,Cui, Di,Sun, Haili,Jiang, Lun,Chen, Zhenhang,Zhang, Rui,Gao, Yina,Wu, Wei,Tang, Jun,Chen, Zhongzhou,Lang, Yue,Cui, Di,Sun, Haili,Zhang, Rui,Tang, Jun,Tian, Wenli.

[11]Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation. Gao, Yina,Liu, Yang,Dong, Xiaofei,Chen, Zhenhang,Tang, Jun,Wu, Wei,Chen, Zhongzhou,Zhang, Qi,Tong, Yufeng,Lang, Yue,Tang, Jun,Tian, Wenli,Tong, Yufeng.

[12]Recent Advances in Developing Photosensitizers for Photodynamic Cancer Therapy. Chen, Cong,Wang, Jianmin,Li, Xiaoyan,Chen, Cong,Wang, Jianmin,Li, Xiaoyan,Liu, Xiaolong,Liu, Xiaolong,Han, Xiao.

[13]The Coronin Family and Human Disease. Liu, Xiaolong,Gao, Yunzhen,Li, Lin,Liu, Jingfeng,Lin, Xiao,Li, Lin,Liu, Jingfeng,Han, Xiao.

[14]A review of recent studies in China on the possible beneficial health effects of tea. Zhu, YX,Huang, H,Tu, YY. 2006

[15]Tea and human health: biomedical functions of tea active components and current issues. Chen, Zong-mao,Lin, Zhi. 2015

[16]Quantification of pegylated liposomal doxorubicin and doxorubicinol in rat plasma by liquid chromatography/electro spray tandem mass spectroscopy: Application to preclinical pharmacokinetic studies. Yang, Yuhui,Liu, Yanhong,Liu, Xiangtao,Jiang, Tao.

[17]Protocol to assess the antitumor efficacy of an immunotherapeutic peptide in syngeneic orthotopic glioma mouse models. Apeng Chen,Yapeng Chao,Han Zou,Lauren H. McCarl,Gary Kohanbash,Baoli Hu. 2023

[18]Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells. Xianjin Kan,Yuncong Yin,Cuiping Song,Lei Tan,Xusheng Qiu,Ying Liao,Weiwei Liu,Songshu Meng,Yingjie Sun,Chan Ding. 2021

[19]Research Progress on the Structure and Function of G3BP. Weifang Kang,Yue Wang,Wenping Yang,Jing Zhang,Haixue Zheng,Dan Li. 2021

[20]Health functions and related molecular mechanisms of ellagitannin-derived urolithins. Gandhi, Gopalsamy Rajiv,Antony, Poovathumkal James,Ceasar, Stanislaus Antony,Silva Vasconcelos, Alan Bruno,Montalvao, Monalisa Martins,Farias de Franca, Mariana Nobre,Resende, Ayane de Sa,Sharanya, Chelankara Suresh,Liu, Yi,Hariharan, Govindasamy,Gan, Ren-You. 2022

作者其他论文 更多>>