数字农科院2.0

Global dynamics of streptococcus agalactiae antibiotic resistance: Past, present, and future

文献类型： 外文期刊

作者： 房辉;;李东航;; 魏夏夏 ;;王仁东;; 苏燕燕 ;;于佑任;; 白航铭;; 高会会;;侯捷;;毛大庆;;罗义

关键词： 无乳链球菌;;基因组分析;;抗菌药物耐药性;;风险预测;;机器学习

期刊名称： JOURNAL OF HAZARDOUS MATERIALS

ISSN： 0304-3894

年卷期： 2025 年

页码：

收录情况： SCIE（2025版） ; ; EI（2025版）

摘要： The rising antibiotic resistance of Group B Streptococcus (GBS) threatens maternal and neonatal health globally. However, global temporal trends of GBS antibiotic resistance – spanning past, present, and future, remain poorly understood, which hinders the development of targeted control measures. We analyzed 1838 GBS genomes from the NCBI database have been analyzed to investigate trends in the abundance, diversity, and polymorphism of single-nucleotide polymorphisms (SNPs) in antibiotic resistance genes (ARGs) over the past 45 years. These findings indicate that GBS harbors ARGs conferring resistance to 9 antibiotic classes, predominantly macrolide, tetracycline, aminoglycoside, and lincosamide resistance genes. Over time, ARG abundance has increased 4-fold, from 1 to 4.67 copies per strain, accompanied by significant increases in ARG diversity and polymorphism. Through geospatial analysis, we identified Asia as a critical hotspot of antimicrobial resistance, exhibiting heightened resistance to aminoglycosides, tetracyclines, and lincosamides, alongside elevated genetic polymorphisms. A random forest prediction model projects a 187 % rise in global GBS resistance risk over two decades, with Asia facing an even sharper increase of 219 %. These findings underscore the urgent need for coordinated global interventions to mitigate resistance and protect vulnerable populations.

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