数字农科院2.0

Identification and Characterization of a Novel Type of Cartilage Stem/ Progenitor Cells from Tibetan Mastiff

文献类型： 外文期刊

作者： Caiyun Ma;Hebao Wen;Lu Li;Gaofeng Liu;Chunjing Wang;Yu Guo;Shiji Fang;Hongyu Wang;Changqing Liu

作者机构：

关键词： Biological properties;Cartilage stem/ progenitor cells;Cell therapies;Differentiation multipotency;Tibetan mastiff

期刊名称： Pakistan Journal of Zoology

ISSN： 0030-9923

年卷期： 2022 年 54.0 卷 6 期

页码：

收录情况： SCIE（2022版）

摘要： Based on the physiologically non-self-renewing property of articular cartilage, the treatment of articular cartilage lesions remains an important challenge. Articular cartilage, the target of osteoarthritis (OA), contains renewable cartilage stem/progenitor cells (CSPCs) to maintain the tissue homeostasis. Compared with other adult stem cells, the self-renewal capacity and preference for chondrogenesis of resident CSPCs have propelled their exciting therapeutic prospects for cartilage repair. Tibetan mastiff, the ancestor of large breed dogs worldwide, represents a valuable model for human diseases. To our knowledge, this is the first study to capture the emergence of Tibetan mastiff-derived CSPCs. Our study aimed to unveil the biological properties and differentiation multipotency of CSPCs. CSPCs were characterized by the clonogenicity, growth curves and karyotype analysis, respectively. The results showed that the CSPCs of Tibetan mastiff displayed self-renewal ability, proliferative potential, and hereditary stability. Moreover, the CSPCs of Tibetan mastiff also positively expressed recognized surface antigens of human CSPCs. Additionally, CSPCs exhibited differentiation multipotency, including osteogenic, adipogenic and chondrogenic potential in vitro. These findings may propell CSPCs application in a clinical study, suggesting potential therapeutic treatment for OA or related joint diseases.

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