数字农科院2.0

Toxic effects of acaricide fenazaquin on development, hemolymph metabolome, and gut microbiome of honeybee (Apis mellifera) larvae

文献类型： 外文期刊

作者： Jiangli Wu;Fengying Liu;Jiajing Sun;Qiaohong Wei;Weipeng Kang;Feng Wang;Chenhuan Zhang;Meijiao Zhao;Shufa Xu;Bin Han

作者机构：

关键词： Energy metabolism;Fenazaquin;Gut microbiota;Hemolymph metabolome;Honeybee;Larval development

期刊名称： Chemosphere

ISSN： 0045-6535

年卷期： 2024 年 358 卷

页码：

收录情况： SCIE（2024版） ; ; EI（2024版）

摘要： Fenazaquin, a potent insecticide widely used to control phytophagous mites, has recently emerged as a potential solution for managing Varroa destructor mites in honeybees. However, the comprehensive impact of fenazaquin on honeybee health remains insufficiently understood. Our current study investigated the acute and chronic toxicity of fenazaquin to honeybee larvae, along with its influence on larval hemolymph metabolism and gut microbiota. Results showed that the acute median lethal dose (LD50) of fenazaquin for honeybee larvae was 1.786 μg/larva, and the chronic LD50 was 1.213 μg/larva. Although chronic exposure to low doses of fenazaquin exhibited no significant effect on larval development, increasing doses of fenazaquin resulted in significant increases in larval mortality, developmental time, and deformity rates. At the metabolic level, high doses of fenazaquin inhibited nucleotide, purine, and lipid metabolism pathways in the larval hemolymph, leading to energy metabolism disorders and physiological dysfunction. Furthermore, high doses of fenazaquin reduced gut microbial diversity and abundance, characterized by decreased relative abundance of functional gut bacterium Lactobacillus kunkeei and increased pathogenic bacterium Melissococcus plutonius. The disrupted gut microbiota, combined with the observed gut tissue damage, could potentially impair food digestion and nutrient absorption in the larvae. Our results provide valuable insights into the complex and diverse effects of fenazaquin on honeybee larvae, establishing an important theoretical basis for applying fenazaquin in beekeeping.

分类号：

  • 相关文献

[1]Enantioselective toxicity of the neonicotinoid dinotefuran on honeybee (Apis mellifera) larvae. Jiajing Sun,Jiangli Wu,Xufeng Zhang,Qiaohong Wei,Weipeng Kang,Feng Wang,Fengying Liu,Meijiao Zhao,Shufa Xu,Bin Han. 2024

[2]Potential role of the gut microbiota of bumblebee Bombus pyrosoma in adaptation to high-altitude habitats. Zhang, Zhengyi,Guo, Yulong,Zhuang, Mingsheng,Liu, Fugang,Xia, Zhongyan,Zhang, Zhihao,Yang, Fan,Zeng, Huayan,Wu, Yueguo,Huang, Jiaxing,Li, Jilian. 2023

[3]Host species and geography differentiate honeybee gut bacterial communities by changing the relative contribution of community assembly processes. Yuan Ge,Zhongwang Jing,Qingyun Diao,Ji Zheng He,Yong Jun Liu. 2021

[4]Acaricide flumethrin-induced sublethal risks in honeybees are associated with gut symbiotic bacterium Gilliamella apicola through microbe-host metabolic interactions. Qi S.,Al Naggar Y.,Li J.,Liu Z.,Xue X.,Wu L.,El-Seedi H.R.,Wang K.. 2022

[5]Combined effects of microplastics and flupyradifurone on gut microbiota and oxidative status of honeybees (Apis mellifera L.). Tong An,Wangjiang Feng,Han Li,Yanyan Wu,Pingli Dai,Yong Jun Liu. 2025

[6]Polystyrene microplastics reduce honeybee survival by disrupting gut microbiota and metabolism. Han Li,Wangjiang Feng,Tong An,Pingli Dai,Yong Jun Liu. 2025

[7]Identification of the proteome complement of high royal jelly producing bees (Apis mellifera) during worker larval development. Zhang, Zhaohui,Pan, Yinghong,Li, Jianke,Li, Huawei,Li, Huawei.

[8]Host fruits shape the changes in the gut microbiota and development of Bactrocera dorsalis (Diptera: Tephritidae) larvae. Akami, Mazarin,Ren, Xueming,Wang, Yaohui,Mansour, Abdelaziz,Cao, Shuai,Qi, Xuewei,Ngakou, Albert,Ngane, Rosalie Annie Ngono,Niu, Chang-Ying. 2022

[9]DNA methylase 1 influences temperature responses and development in the invasive pest Tuta absoluta. Tang, Yanhong,Zhang, Huifang,Zhu, Huanqing,Bi, Siyan,Wang, Xiaodi,Ji, Shunxia,Ji, Jianhang,Ma, Dongfang,Huang, Cong,Zhang, Guifen,Yang, Nianwan,Wan, Fanghao,Lue, Zhichuang,Liu, Wanxue. 2024

[10]Estimation of the maintenance energy requirements, methane emissions and nitrogen utilization efficiency of two suckler cow genotypes. Zou, C. X.,Lively, F. O.,Wylie, A. R. G.,Yan, T.,Zou, C. X..

[11]Subtraction suppressive hybridisation analysis of differentially expressed genes associated with puberty in the goat hypothalamus. Cao, G. L.,Feng, T.,Chu, M. X.,Di, R.,Huang, D. W.,Liu, Q. Y.,Hu, W. P.,Wang, X. Y.,Cao, G. L.,Zhang, Y. L.,Feng, T.. 2016

[12]Aluminum chloride caused liver dysfunction and mitochondrial energy metabolism disorder in rat. Xu, Feibo,Liu, Yanfen,Yu, Kaiyuan,Song, Miao,Li, Yanfei,Liu, Yanfen,Zhu, Yanzhu,Zhao, Hansong.

[13]Study on energy metabolism of dairy buffalo heifers in Guangxi, China. Zou, C. X.,Liang, X. W.,Yang, B. Z.,Liang, K.,Wei, S. J.,Zou, C. X.,Liu, J. X.,Xia, Z. S.,Zhao, F.. 2007

[14]Comparison of blood variables, fiber intensity, and muscle metabolites in hot-boned muscles from electrical- and gas-stunned broilers. Xu, L.,Yue, H. Y.,Wu, S. G.,Zhang, H. J.,Ji, F.,Zhang, L.,Qi, G. H..

[15]Nutritional and physiological responses of finishing pigs exposed to a permanent heat exposure during three weeks. Hao, Yue,Feng, Yuejin,Yang, Peige,Feng, Jinghai,Gu, Xianhong,Lin, Hai.

[16]Feeding during the resting phase causes profound changes in physiology and desynchronization between liver and muscle rhythms of rats. Opperhuizen, Anne-Loes,Wang, Dawei,Jansen, Remi,de Vries, Janneke,Kalsbeek, Andries,Wang, Dawei,Foppen, Ewout,Boudzovitch-Surovtseva, Olga,Fliers, Eric,Kalsbeek, Andries. 2016

[17]Induction of copper and iron in acute cold-stimulated brown adipose tissues. Wang, Chao,Liang, Xiaojuan,Tao, Cong,Yao, Xiaolei,Wang, Yajun,Wang, Yanfang,Li, Kui,Yao, Xiaolei.

[18]Comparative proteomic and bioinformatic analysis of Theileria luwenshuni and Theileria uilenbergi. Zhang, Xiao,Li, Youquan,Chen, Ze,Liu, Zhijie,Ren, Qiaoyun,Yang, Jifei,Zhu, Xinquan,Guan, Guiquan,Liu, Aihong,Luo, Jianxun,Yin, Hong,Zhang, Xiao,Li, Youquan,Chen, Ze,Liu, Zhijie,Ren, Qiaoyun,Yang, Jifei,Zhu, Xinquan,Guan, Guiquan,Liu, Aihong,Luo, Jianxun,Yin, Hong,Zhang, Xiao,Li, Youquan,Chen, Ze,Liu, Zhijie,Ren, Qiaoyun,Yang, Jifei,Zhu, Xinquan,Guan, Guiquan,Liu, Aihong,Luo, Jianxun,Yin, Hong.

[19]Uncoupling Protein 3 Promotes the Myogenic Differentiation of Type IIb Myotubes in C2C12 Cells. Ziwei You,Jieyu Wang,Faliang Li,Wei Hei,Meng Li,Xiaohong Guo,Pengfei Gao,Guoqing Cao,Chunbo Cai,Bugao Li. 2023

[20]Roles of GFAT and PFK genes in energy metabolism of brown planthopper, Nilaparvata lugens. Hui Ru Si,Si Si Sun,Yong Kang Liu,Ling Yu Qiu,Bin Tang,Fang Liu,Qiang Fu,Cai Di Xu,Pin Jun Wan. 2023

作者其他论文 更多>>