数字农科院2.0

Yellow leaf green tea modulates the AMPK/ACC/SREBP1c signaling pathway and gut microbiota in high-fat diet-induced mice to alleviate obesity

文献类型： 外文期刊

作者： Tian, Baoming;Pan, Yizhu;Zhou, Xue;Jiang, Yuezhi;Zhang, Xiangchun;Luo, Xudong;Yang, Kai

作者机构：

关键词： energy metabolism;fecal microbiota transplantation;high-fat diets;obesity;yellow leaf green tea

期刊名称： JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

ISSN： 0022-5142

年卷期： 2024 年

页码：

收录情况： SCIE（2024版）

摘要： BACKGROUND: Yellow leaf green tea (YLGT) is a new variety of Camellia sinensis (L.) O. Ktze, which has yellow leaves and the unique qualities of 'three green through three yellow'. The present study aimed to investigate the anti-obesity effect of YLGT in mice fed a high-fat diet (HFD) and to explore the potential mechanisms by regulating the AMPK/ACC/SREBP1c signaling pathways and gut microbiota. RESULTS: The results showed that YLGT aqueous extract reduced body weight, hepatic inflammation, fat accumulation and hyperlipidemia in HFD-induced C57BL/6J mice, and also accelerated energy metabolism, reduced fat synthesis and suppressed obesity by activating the AMPK/CPT-1 alpha signaling pathway and inhibiting the FAS/ACC/SREBP-1c signaling pathway. Fecal microbiota transplantation experiment further confirmed that the alteration of gut microbiota (e.g. increasing unclassified_Muribaculaceae and decreasing Colidextribacter) might be an important cause of YLGT water extract inhibiting obesity. CONCLUSION: In conclusion, YLGT has a broad application prospect in the treatment of obesity and the development of anti-obesity function beverages. (c) 2024 Society of Chemical Industry.

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