Study on a growth promoting effect and mechanism of the extract of stem and leaf from Atractylodes lancea DC. on nile tilapia
文献类型: 外文期刊
作者: Tian, Wei;Wang, Ziying;Shi, Dongdong;Huang, Zhiwei;Liu, Yuefei;Li, Xiumei
作者机构:
关键词: Atractylodes lancea DC;stems and leaves;extracts;growth promoting effect;mechanism
期刊名称: NATURAL PRODUCT RESEARCH
ISSN: 1478-6419
年卷期: 2025 年
页码:
收录情况: SCIE(2025版)
摘要: Atractylodes stems and leaves, often discarded as waste, were investigated for their growth-promoting effects and chemical composition. This study evaluated Atractylodes lancea DC. extract (ALE) on Lactiplantibacillus plantarum growth, with optimal treatment at 7.5 mg/mL for 24 h. ALE's effects on Nile tilapia were also assessed using 120 juvenile fish fed diets with different ALE doses (0.2%, 0.4%, 0.8%) for 31 days. Results showed that ALE significantly improved fish growth, survival, and intestinal health. Network pharmacology suggested that key compounds (rutin, luteolin) promoted growth through the PI3K-Akt pathways. Rutin and luteolin in ALE were confirmed by HPLC with authentic standards. RT-qPCR further showed that ALE activated the Grb2/PI3K/Akt signalling pathway in tilapia, supporting the predicted growth-related mechanism, and highlighting ALE's potential for sustainable aquaculture.
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